I am on day 8 of Efudex, face, and ears. I thought maybe I didn't really get Efudex because until today I had only 1 spot above my lips. Mind you, I've been thirsty, tired and slightly queasy, and have a lack of appetite. Today I seem to be developing polka dots. I'm in Ohio where it's been cool and raining. I read on the net that heat and sunshine makes the Efudex blossom sooner. I'm not in pain or facial discomfort-yet. I feel a little sore and dry around my nose. I've been reading everyone else's accounts to gauge my reaction. I am supposed to take Efudex for 14 days. I guess I assume each polka dot was a source of sun damaged skin and potential AK. I had several AK's removed from my face previously. (Also I had a Melanoma removed from my neck). After face and ears I'm supposed to start treatment with 'FU' as we affectionately call it, on arms, neck, upper chest and back of hands. BTW I purchased brand name Efudex for 53.00 from a Canadian pharmacy. I know you just can't trust the Canuks. :)