I did have a rash and significant dry skin from erbitux. I referred to it as full body dandruff. Lots of lotion does help as did an antibiotic prescribed for the rash.
I did have severe diarrhea with the irinotecan. I was finally able to control it by taking lomotil. Immodium did not help me much. Others swear by tincture of opium. There are lots of possible ways to treat the diarrhea which can be quite miserable. I was having 20 or more bowel movements per day.
Sally