My husband had 3 rounds of Cisplatin and 5FU every 3 weeks, along with with daily radiation, given over 5 days each due to the nausea. He had Zofran- helped some, Ativan- helped some, Compazine- didn't help at all. We finally tried Emend the last 2 rounds- he took it 1 hour prior to chemo and it was the most helpful. Still nauseated and needed the Zofran and Ativan, but it was much better.