My husband worked for 11 months after starting chemo (Temodar at first). But, he came home every day exhausted and fell asleep by 6, then had a horrible time getting up and getting out the door the next morning. And his boss was very lenient and undemanding of him. Though we didn't need the money that much, he wanted to work because he felt he was useless if he did not. I think physically he might have felt better if he rested and did not work, but mentally he would have become too depressed, so you have to look at the individual and their situation.