Yes, my brother is receivng Thalidomide and Timodar for metastatic melanoma spread to the lungs and adrenal glands. It makes him feel really bad. He is very groggy all the time and on what he calls "double dose" day...that is when he has to take 2 Timodar, then he is really feeling bad the next day. I ask him how he feels and he just says, "bad" so I don't know exactly how it makes him feel. He is becoming an invalid though because he feels like he cannot safely walk. Does it affect you that way?