I've just completed my 5th month of bi-monthly Avastin/CPT-11 treatments, hoping to go on indefinitely. No tumor regrowth since surgery in Septemer 07. The only side effect I've had from CPT-11 (ironotecan) is diarrhea. It was pretty severe a few weeks ago, but I seem to have outlasted it and it's been lessening the past couple of treatments. From what I've read about carboplatin its most worrisome
possible side effect is myelosuppression where platelets a white cell counts are lowered. There are many in neuroncology who believe changing chemo combos every once in a while may have the ability to 'fool' those little tentacles into not reforming into a tumor. There are others who believe you should stick with a winner. If it's working and the tumor is stable, why change? Probably doesn't help much but I understand your angst.