I think I replied to you but I will say it again. I have a friend in a similar situation and got her compassionate use of DAVANAT/5FU and AVASTIN. Like your husband she was taking Delodid for pain due to the bone metastis and just wanted it to be over. Well thanks to her husband fighting she got the DAVANAT mix in the nick of time. Because the DAVANAT targets the chemo so effectively she was off the Delodid in 3 days and downtown shopping in 5 days. Now six weeks later she is on her 4th cyle of chemo and hasn't needed a blood transfusion or anything. You wouldn't have a clue she has been through 3 rounds of chemo. You shouldn't give up. Research DAVANAT - it makes the chemo way more effective and since there are no side effects you have nothing to lose and everything to gain. I think your husband would qualify for a compassionate use study. Call the drug company talk to your doctor - at least try.