My father was recently diagnosed with MF and I am gaining vast knowledge on the subject however there is still much I wish to ask. He has very low platelets and a very enlarged spleen. Drs are suggesting splenectomy. Also are suggesting he take Hydroxyurea. By definition this seems to contradict his symptoms. (Spleen enlargement is not as responsive to hydroxyurea and might require a higher dose (2-3 grams/day). (stated on the MPD website) This may worsen anemia or low platelet counts) I am confused. I also worry that splenectomy will lead to liver problems. He is transfusion dependant 2x wk. This diagnosis has been devistating and releiving at the same time. We knew something was wrong when he kept losing weight and his energy was so low. Now we know why.