Hello all! My mother was diagnosed in Sept. 07 and had treatment for EC of the GE Junction. She had 6 weeks chemo and radiation, then surgery in Jan. 08. A lymph node was found near her left collar bone and it came back malignant. She is now on Taxotere and Epirubicin. She has ulcers in her mouth, not wanting to eat much and really depressed. She is currently on an antibiotic due to Neutropenia, so it is helping with the ulcers in her mouth. I am sure that is causing a decrease in her appetite. She is taking 1 tbsp. of Megase daily, but I don't see a difference in her appetite. She's taking Celexa for depression, but I don't see it making much of a difference. She doesn't have many up days, so I am curious as to what difference it is suppose to make. I know that she will be down, but I do expect her to want to fight. Does anyone have experience with this combination of chemo? Any suggestions about the depression battle and appetite issues? I know she doesn't want to be on a feeding tube, so hopefully she will regain her appetite on her own. Thanks for you response, be blessed and stay encouraged.