Joe - my heart goes out to your and your father. I have had 3 stage III melanomas within a short period of time. If the wait for another opinion and valuable time doesn't get lost, would you consider another opinion at MD Anderson or some other respected cancer center? If there is no other option, I would probably do the trial. Good things happen with prayer and I will pray that the right decision will be made for your father and that it works! Tara