I was diagnosed with multiple myeloma stage two in April 2007 and was immediately given thalidamide and 40 dex.I continued this dosage until I complained about the effect the dex was causing after the four day cycle. I was then told to take the dex once a week only with the thalidamide. Following this change I was told the thalidamide/dex wasn't working so they put me on revlamid and dex for two cycles and again was told this wasn't working either and was started on velcade which is where I am presently. I am told that I've gone from a 2.8 to a 3.2 "M Spike" and now am at a 3.0 since I've been given the velcade. I am scheduled to start autologus stem cell transplant the 22 of this month but will not be allowed unless my "M Spike" is down and I am moving toward remission. How dramatic is changing from a 3.2 to a 3.0 "M Spike"? Forgive but do people without cancer have a "M Spike" ? The nurse told me that unless I respond to the chemo meds that I will not be allowed the stem cell and there would be no use to continue giving me the cancer fighting drugs. I am starting to feel like it's all to no avail. If anyone has an input into my plight I would appreciate hearing from you.