FeelAnew----this is what the box states......Joint Comfort Glucosamine & Chondroitin with Nexrutine. From reading the box Nerutine is a patent-pending natural COX-2 inhibitor. I found this product in Vitamin Shoppe (I live in New York) I have found that my knees and feets do not hurt as much since I have been taking this product (about 8 weeks) I hope this info has been helpful!!