Thankyou OncRX for your time to respond to my message. It was reassuring to hear that the sit and wait approach is probabaly the most appropriate thing to do. During our post op appointment with the surgeon who removed the metastasis to my father's adrenal gland he said that what he could see of the liver, it looked OK. We are concerned about the effectiveness of Folox if after 6 cycles the tumor had remained the same size, you would hope that the tumor would decrease in size ? The onco also mentioned that if new tumor(s) appear in future that he would put my father onto Irinotecan. I am concerned about the effectiveness of this on reducing progression if the Folox which is reported to have significantly better results only seemed to stop the progression to the tumor whilst his CEA went to 74. Since the cancer has spread from the right colon to the right adrenal gland would local radiotherapy be of any benefit? Would be great to hear back from you or anyone else with a similiar experience to share. Thanks again.