Sorry if I can't be much help, but I will try. I'm an ovarian cancer survivor and know that depression is definitely a side effect of the treatment/diagnosis of any cancer. I was drawn to your message because my father had multiple myeloma. He was treated with oral chemotherapy (don't even know what) and went into remission for seven years. He has since passed on, but I was impressed with the treatment results after hearing his original prognosis. Stem cell transplant is being used more since then and I don't know what side effects you should expect, but from experience, your husband probably needs some medication for depression. I am all too familiar with wanting to be alone, not wanting to talk to anyone, staying away from social functions--just feeling different and helpless. He really needs you now, but tread lightly. He'll soon realize he needs the support of others. There are several books that I've found worth reading--is he a reader? Have you gotten a second or third opinion on treatment options?