I started out taking a teaspoon 2x a day last fall.(2004) One of the doctors that works for Mannatech told my friend that if you have an illness, you can take up to a tablespoon 2x a day. The more the better! It won't hurt you, it's just like food. It's not herbal or medicinal. I now take 1/4 teaspoon 2x a day, like the container recommends. Also, I take the Ambrotose bulk, which is the powder. You also have to stay on it for at least 3-4 months sometimes to see results. The first week or two, it made my face break out a little and I had a few minor headaches, but I was told that might happen because your cells are reacting to a change in your body. Apparently if you have any of those things occur, that means it's helping. They went away after the first 2 weeks and I felt great! It also helps mental alertness, which can sometimes be a problem when you have liver cancer or tumors. I noticed a difference after about 4 weeks. Hope this info helps!