I am just about to start my second round of Temodar. The first round was pretty easy on me. I took it every day for 42 days while I was doing radiation. I just took it at night with Zofran (anti-nausea drug). And the only side effect I had was constipation, but that was solved by eating extra fiber/metamusal. I lost some hair too, but I ascribe that to the radiation not the Temodar. Good luck.