The oncology nurse called today and said the Dr wanted me to add a perscription for Celebrex (an arthritis drug)to my daily regimine of Tarceva. He says some studies have shown it improves the effectiveness of the Tarceva. I will find out more on Monday at my appointment. My rash is much better than when I first started, most people say they don't even notice it. But it moves around like you say. A few weeks ago I had a lot of pimples on my hands and arms. When I was on the reduced dosage, all of the side effects cleared. Now the sores in the nose and the diahrrea and cracked skin on my fingertips are bad again since I started the 150 mg. again. Almost like starting all over again. I would be afraid to go higher than 150 though. My Dr said the side effects would diminish in time, but not as an indicator of the effectiveness of the drug. Will let you know the outcome Monday.