Hi MacDog-
My dad started Tarceva 150mg in mid-Dec 2005. About a week after he broke out in a huge rash all over his chest and on his face (nose and cheeks, as well as behind his ears and back of his neck.) It all turned into one large scab pretty much on his face. He was extrememly uncomfortable so his dosage was cut in half as he was put on an antibiotic (not sure which one, i'm sorry!). His rash began to go away, once it cleared up and we had our followup appointment with his oncologist jan 9, he was told to hop right back on 150mg a day and has had very very slight signs of it on his skin, but nothing like the first time. I read a lot that when first on Tarceva oftentimes the skin will break out like it did the first time, but only once and once your body is used to the Tarceva it calms down greatly. He has been back on the 150mg dose for over 2 weeks now and his skin is really fine and he is more comfortable. We still need to wait till Mid-march to see how he is responsding to Tarceva since he was only diagnosed with stage iv nsclc in late november. Hope this helps you and I wish you well.