Hi Everose, my wife has been on tarceva for 10 months now. She has been extremely lucky in that she's not had hardly any facial skin rash that all our Dr's and nurses said was the most often seen symptom. She is very tired and get's fatigued quite easily. She also has the spells of on/off diarreah too. One of our biggest problems is keeping her weight up. She was a small framed - 102 lbs woman at the beginning of our fight and many many times I can't get her to eat "enough", so her weight fluctuates between 90 and 96 lbs. We use Ensure and she tries to eat a little, 4 - 5 times a day. She also has the "shakes" at time - - - not all day long, just when she goes overboard and get's extremely fatigued, after a bad coughing spell or even when she yawns or sneeze's too much ! She does have the painful skin problem on her toes (like Kimflordia had) and that's a big problem as she's got a toe fungus also ! Using a scrip. med for that but it's not helping too much. Many day's I have to push and shove her to get her going ! Don't let your husband get too depressed - - if he does let your Doctor's know !!!! Her cancer is inoperable too and has spread to the bone and liver. They gave her 2 yrs. in Feb ....... so I told them we'd come back in 5 yrs. just to prove them wrong ! ha! You hang in there, enjoy the Holiday's and if you agree - - keep praying ! We've got 10 grandkids all up in Indy and my wife use's that as her motivation to keep fighting -(maybe a little "me" too). We'll keep you and your husband in our prayer's !