Kim - Thanks for your answer to my question about the side effects of Tarceva. My husband hasn't been on it long enough for all those things to appear. Is your tumor shrinking? How soon did you know and how did you know? He is now experiencing a feeling as if he is very, very cold and noone seems to know what to do other than telling him to dress warmly and put on blankets. I'm wondering if this is another side effect or maybe from his depression? Who knows? It is a daily battle, isn't it? Eve