Fighters (and what a great name) Thanks for your answer to my question about the side effects of Tarceva. My husband is having the weight problem also. He started at 165 and is now down to 130. He is very cold all the time and the doctor thinks it is because of the weight loss. Do you think the Tarceva is helping shrink your wife's tumor? That is certainly the result we are hoping for. We have 6 grandchildren and they are also an inspiration for us. I - like you - would never accept anyone telling me the amount of time I have to live. Just keep fighting and keep a positive attitude. The role of caretaker is not an easy one. We have been together 50 years. I'm not giving up!!!! Eve