I know you posted your question awhile ago. I hope your husband is doing better. I was on Folfox and hated the oxaliplatins side effects. Cold intolerance and numbness and tingling. But it was the 5FU that nearly did me in. Fortunately my GI doctor recognize I was severely malnourished and put me on TPN ( intravenous nutrition) at home. I was able to eat but I was not digesting my foods because I was not making the enzymes needed. My doc put me on Creon (enzymes) and I responded very well. I gained weight and got a little energy back.
I had to switch to Folfiri and Erbitux and the only downside was my WBC's dropped. However I keep getting infections so I am going to take prophylactic antibiotics with chemo, now.
Hope this helps someone.