I have had two treatments so far for my ovarian cancer. After each of the sessions I suffered severe ankle and knee pain with accompanying radiating pain in my lower legs and feet. Heat seemed to make it worse. Cold compresses sometimes alleviated the pain, but not always. The pain lasts over 2 weeks with the first week after the treatment being the worst. All percosett did was make me sicker! Advil (600mg) only took the edge off. I am due for another treatment soon and I am dreading it. Has anyone experienced this and what did they do for it? I will be eternally grateful!