Have you and your family considered seeking a second opinion? My aunt was just recently diagnosed with Bile Duct cancer. The first doctor she saw said there was not much hope and not much they can do. He said surgery was not an option because the cancer is on the side where the liver functions. the cancer has also spread to her pancreas. My family was not happy with the hopeless news and sought a second opinion. They took my aunt to Roswell Cancer Center in Buffalo NY. It is a very roknown cancer center that does a lot of research. There we found hope. However, this cancer is not cureable but they have been doing reasearch and studies for over the past 10 years and are at the point of introducing their treatment into the market within the next couple of months. It has given patients with bile duct cancer a few more years to live and more comfort through those years. I am not sure where you live but I would consider talking your sister into visiting this cancer center. My aunt was given 6 mos to 2 years to live with the prognosis from the first doctor, and now she has a chance to live even a few more comfortable years with this treatment. Please consider.