Mike,
Sorry to hear your wife has glioblastoma, but it sounds like her condition is stable, which is encouraging. With this disease, it's essential to take things one day at a time,and not to look too far ahead.
I live in South Bend, Indiana. My hematologist is Dr. David Taber. When I started chemo, I took the full daily dose at once, but did not tolerate it very well. I switched to two pills and things were better. I would come home from work at 3:45, take the first pill, and then nap for an hour or so. I would take the second pill just before bedtime, that way I could sleep off the effects. I preferred Ativan to Kytril, because its effects are milder. The kytril dehydrated me too much. Unfortunately, the Ativan is somewhat addictive, but I found I was able to stop it without too much difficulty. There are many other anti-nausea medications, so be sure your wife asks for an alternative, if she finds the side effects of any one of them too unpleasant. Whichever one she chooses, be sure she drinks plenty of water. Hydration is critical during chemo.
By the bye, my latest scan showed no changes, so I continue to be in remission. I hope your wife will be able to say the same three and a half yearsfrom now. - Brian