hey mary thanks for your reply,i'm tring my best to think positive but its getting harder and harder every day. just when we thought we were ahead of this disease it seems like its always a step ahead of us,its almost getting to a point to where were not getting anywhere. i asked the dr. when he was going to start my husband on sutent he said: after he has had brain surgery. i just don't understand whats the differenceif he starts now or after the surgery?????????thanks lou