My husband started his battle with RCC in 1999 losing his left kidney. Mets to bone caused hypercalcemia. Zometa 15 min infusions Jan 2003 to Sep 2004. Left hip, femur, knee and half of shin bone replaced with metal in Oct 2004. Hypercalcemia returned Aug 2005 New tumors in soft tissue of left hip/buttock removed Nov 2005. Hypercalcemia returned Dec 2005. Started Sutent 3/1/2006. First three rounds calcium dropped to normal range. July 2006 Hypercalcemia climbed. Sept 2006 gone from high panic to critical of 15, hospitalized given hydration, Lasix, calcitonin, steriods dropped for about month then back to hospital for repeat first Nov. Treatment less effective. Headed back to hospital this week as calcium again over 12 and Nephrologists can only say "difficult case". Anyone know of any other treatment for hypercalcemia? RCCRebel