I am in my 3rd year of treatment for stage 3 ovarian. my tumor marker climbed back to 80 8 months ago and I was started on Doxil. I had a severe reaction after 2 treatments, i.e., my hands swelling to the point I could not use them - very painful, and some swelling in my feet. The treatments were changed. I'm now on Topotecan (Hycamtin), which is keeping it in check, the marker now down to 41. This is all I can tell you except to know not all experience the same side-effects.