Hi. My mother has been taking chemo for ovarian cancer off and on for almost 5 years. Recently she was taking Topotecan (for about 2 years) and her CA-125 began to rise. She was put on the Doxil (along with 3 other women locally). I hovered over her for about 4 days after each treatment and because she took it easy (no hot foods or beverages, no hot baths, lounging in loose clothing, etc) she never had a bit of trouble, and I thank God for that. However, after 3 treatments, she and the other women that had been put on the Doxil were all taken off - their CA-125 numbers shot through the roof (into the thousands)...She is now back on Taxol and Carboplatin and by the grace of God, her numbers have been going down. Good luck with the Doxil, but keep a close watch on your counts, and you need to take it extremely easy for a few days after each treatment and you may not have any of the rashes, etc. Good Luck!