Please help us to figure this all out! My mother, last week on her 67th birthday, was diagnosed with inoperable metastatic melanoma in the rectum with mets to the liver. They removed part of the primary tumor in the rectum but could not get the whole thing. Her oncologist is recommending looking at clinical trials but when I registered her with Dana Farber, I received 44 possible studies in the U.S. How do we begin to even analyze these? Is there anything out there that has even some good effect? Otherwise, she can go on the standard chemo of Temzolomide but I understand that it is not that effective. Please give us some guidance - we are at an absolute loss. She is willing to go anywhere if there is some good promise in the program. Any advice is welcome. Thank you.