CancerCompass message board discussion started by Sally-Arctic on 11/2/2007 http://www.cancercompass.com/message-board/message/all,17598,0.htm Sun, 06 Jul 2008 00:00:00 GMT Sun, 06 Jul 2008 00:00:00 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/ Can anyone give me information about "AVE'" wheat-germ extract for complimentary therapy in Breast-cancer treatment? Thanks Sally-Arctic Fri, 02 Nov 2007 00:00:00 GMT I have a few websites with some excellent information regarding clinical trials etc. for Avemar (AVE in the USA) which I have been trying to post here and also send you via private message but for some reason I keep getting a "timed out" message. I will attempt to contact you through private message with my E mail address and relay the message that way. Best regards Shemay On 11/2/2007 Sally-Arctic wrote:Can anyone give me information about "AVE'" wheat-germ extract for complimentary therapy in Breast-cancer treatment? Thanks Shemay Fri, 02 Nov 2007 00:00:00 GMT CHICAGO -- A fermented wheat germ extract inhibits estrogen positive and estrogen negative breast cancer tumors better than the world's best selling cancer drug, Tamoxifen, according to research published this past weekend at the 2007 meeting of the American Society of Clinical Oncology, ASCO. The compound, Avemar, has been extensively studied in many cell lines, animal tumor models, and several human clinical trials. In the current study, Andras Telekes, MD, Ph.D., head physician at the Hungarian National Institute of Oncology, and colleagues, implanted estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast tumors from humans and mouse cell lines into female mice and monitored tumor growth. They compared tumor growth in mice treated with Avemar alone, or treated with three of the most widely used and studied breast cancer drugs: Tamoxifen, Aromasin, or Arimidex, alone, and combinations of those drugs with Avemar. Against the mouse ER+ cell line, MXT, Avemar inhibited growth by 50%, Aromasin by 46.7%, Tamoxifen by 34% and Arimidex by 29.3%. Against the human ER+ cell line, T47T, Avemar inhibited growth by 49%, Tamoxifen 42%, Aromasin 25% and Arimidex 25%. Each agent was enhanced by 5 to 10% when combined with Avemar. Most effective was a combination of Aromasin and Avemar, inhibiting both the mouse and human derived ER+ breast tumors by 60%. Effects against estrogen receptor-negative (ER-) breast cancer were measured with the human derived, MDA-MB-231 cell line. Estrogen-blocking drugs are not effective against ER- breast cancers, so they were not tested in this tumor model. However, Avemar did inhibit the growth of the ER-negative MDA-MB-231 breast tumors significantly (52%), suggesting to researchers that the mechanism by which the extract works is different from that of the anti- estrogen drugs, and is independent of a breast tumor's estrogen receptor status. Avemar's efficacy against both ER+ and ER- tumor types suggests the compound's mechanisms of action against breast cancer may be those that inhibited tumor growth in other cancers, including lung, pancreatic, colon, melanoma, leukemia, and other breast cancer lines, among others, against which the compound has also been tested. Chief among these mechanisms is its ability to interfere with the excess use of glucose by cancer cells (the Warburg effect), which interferes with the synthesis of DNA needed for cell proliferation. Avemar is produced by Biromedicina, RT of Budapest, Hungary through a patented process (US no. 6,355,474) and standardized for content of methoxy- substituted benzoquinones. The Hungarian Ministry of Health has approved Avemar as a "medical food," with an on-label indication in the treatment of colorectal and other cancers. Avemar, distributed by Blauvelt, NY American BioSciences in the US as the dietary supplement Ave, is available nationwide through vitamin retailers, doctors, pharmacies. Avemar research is available via the National Library of Medicine website, using the search term Avemar. Shemay Fri, 02 Nov 2007 00:00:00 GMT Thank you so much for your prompt reply. This looks like a very promising inclusion in treatment protocols. Sally Sally-Arctic Fri, 02 Nov 2007 00:00:00 GMT  On 11/2/2007 Sally-Arctic wrote:Thank you so much for your prompt reply. This looks like a very promising inclusion in treatment protocols. SallySally,I'm not sure where you are located but Mate Hidvegi, discoverer of the natural compound, Avemar, is visiting the US to present results of new Avemar studies.  There will be a lecture at the Teaneck Marriott at Glenpointe in Teaneck, NJ on May 7th, 7:00 - 8:30pm.  There is a RSVP by may 5th to Ann Marie at 845-848-8009.  Maybe she'll be able to tell you where else the lectures will be in the US if this one is not convenient to you.   2ndChance Thu, 01 May 2008 00:00:00 GMT It would sure be beneficial if you posted everything, except for those posts  that are truly personal, for all of us so that we can review all of the information.  I just checked the test that are being done overseas and the bottom line is that there are no tests or trials that show that Ave was used alone.  I was used in combination with standard chemo (folfox, etc that I used) and surgery plus radiation in some cases.  It was stated clearly thatf it was used as a supplemment that it COULD help improve, in some cases. the side effects.  I would still like to see that test or trial that states that  alternatives will cure any form of cancer alone. You lead us to believe that the traditional approach is less effective and less desired  My position was, if you recall, that a COMBINATION of the alternative, along with corrective surgery, radiation and chemo could provide the best results Arnold Thu, 12 Jun 2008 00:00:00 GMT My last post is for Shemay Arnold Thu, 12 Jun 2008 00:00:00 GMT