CancerCompass message board discussion started by photopaul on 11/23/2007 http://www.cancercompass.com/message-board/message/all,18273,0.htm Tue, 07 Oct 2008 00:00:00 GMT Tue, 07 Oct 2008 00:00:00 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/ In general, there does not appear to be much research connecting MM & Celiac's disease but I think the following extract from a paper published in Leukemia Research in 2006 will be of interest:"Multiple myeloma is malignant disease that is characterized in most patients, by the presence in the serum of monoclonal gamma globulins, which in agarose gel after electrophoresis appear as protein band of restricted mobility, "M" component. The aim of this study was to determine are the antibodies contained in M-component directed to some antigen chronically present in the organism, to some of food antigens. Seventeen patients with secretory plasmacytoma were included in the study: eight of them had IgG(kappa), three had IgG(lambda), and one had biclonal IgG(kappa) and IgA(kappa), while two had IgA(kappa), the other two IgA(lambda) and one IgM(lambda) as paraproteins. M-proteins were detected analyzing patients' sera by agarose gel electrophoresis in 0.09 M barbital buffer. The each M-protein was confirmed by immunotyping (immunofixation) with corresponding antihuman antibodies directed to heavy or light chains of immunoglobulins. After the patients serum separation on agarose gel by electrophoresis, fresh 0.4% solution of crude gliadin (Sigma) in 1% SDS was put over the slides for immunoprecipitation. Preliminary results showed the interaction of gliadin with patient's serum proteins present in the protein fraction of the same mobility as it was the mobility of the M-component, in 6 from 17 investigated sera. These results are the first reporting that in sera of some patients with multiple myeloma antibodies from M-component could be directed to some of gliadin antigens. As the serum antigliadin immunoreactivity is present in'patients with gluten intolerance, celiac disease, it could be of importance to elucidate is the multiple myeloma more severe form of gluten intolerance than celiac disease."We might now have a link that, in this limited sample, was relevant in 35% of the patients tested. The research was apparently conducted in one of the former Yugoslavian or Czechoslovakian countries, hence the minor errors in translation.Paul photopaul Fri, 23 Nov 2007 00:00:00 GMT Hi Paul -- Glad you've started a new line --the other was getting quite long!  Have you found anyone else looking into the relationship between MM and Celiac?  Surely the results of this study are significant and deserve someone to continue looking into it?!  Cath poppy/cath Mon, 26 Nov 2007 00:00:00 GMT Hi Cath,I started the new line by accident and I've copied this to the old one. Actually, I would prefer to keep yo the old one because all the comments will be together then.Craig is very interested in the link between celiacs disease and myeloma. We are still not sure which comes first though.Paul photopaul Mon, 26 Nov 2007 00:00:00 GMT