CancerCompass message board discussion started by Alejandrahe on 3/28/2008 http://www.cancercompass.com/message-board/message/all,22425,0.htm Fri, 29 Aug 2008 00:00:00 GMT Fri, 29 Aug 2008 00:00:00 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/  I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡Alejandra     Alejandrahe Fri, 28 Mar 2008 00:00:00 GMT God Bless you too Alejandra    Following is information regarding common side effects of this treatment from one of your links. I have never taken chemotherapy so perhaps these are considered mild in comparison but I personally would not be comfortable putting my body through this. Bexxar is given intravenously once a week for two weeks. The most common side effects occurring in the clinical trials included neutropenia, thrombocytopenia and anemia that can be both prolonged and severe. Of 230 patients included in the safety data from five clinical trials, 63 percent had documented Grade 3 or 4 neutropenia, 53 percent had Grade 3 or 4 thrombocytopenia, and 29 percent had Grade 3 or 4 anemia. Twenty-seven percent of patients received one or more blood transfusions or blood cell growth factors, eight percent of patients experienced a serious infection and 12 percent experienced bleeding events; the majority were mild to moderate. The most common non-hematologic side effects included asthenia (weakness), fever, nausea, infection and cough. The BEXXAR therapeutic regimen was associated with a risk of hypothyroidism and human anti-murine antibody (HAMA) formation. Certain chemotherapy agents and ionizing radiation have been associated with the development of myelodysplasia (MDS), secondary leukemia and solid tumors. MDS, secondary leukemia and solid tumors have also been observed in patients receiving the BEXXAR therapeutic regimen. BEXXAR carries a warning about infusion-related reactions that may be induced by the administration of foreign proteins. Hypersensitivity reactions occurred in six percent of patients. Adjustments of the rate of infusion to control adverse reactions occurred in seven percent of patients.On 3/28/2008 Alejandrahe wrote: I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? " target="_blank" rel="nofollow">http://www.patientadvocate.org/index.php? " target="_blank" rel="nofollow">http://www.patientadvocate.org/index.php? " target="_blank" rel="nofollow">http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm l" target="_blank" rel="nofollow">http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm " target="_blank" rel="nofollow">http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡Alejandra     Shemay Fri, 28 Mar 2008 00:00:00 GMT  On 3/28/2008 Alejandrahe wrote: I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡AlejandraI have also been wondering why more people have not received Bexxar .Ireceived it in May of 2005 after going through CHOP chemotherapy. Iwas on a clinical trial .The first  for the Oncology center I was at. I have been in remission for almost 3 years and my doctor says I am doing fine. It was not with out a lot of side effects ,but like you I would like to know why it is not used more .Ido know that there are alot of different types of NHL and it is not used for all kinds. I would not know how to advise anyone because I don't know how I would have been had I not received it. Iwould like to know what you decide and how you get along with it. Best to you      Carolyn      jucarthom Mon, 31 Mar 2008 00:00:00 GMT  On 3/31/2008 jucarthom wrote: On 3/28/2008 Alejandrahe wrote: I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡AlejandraI have also been wondering why more people have not received Bexxar .Ireceived it in May of 2005 after going through CHOP chemotherapy. Iwas on a clinical trial .The first  for the Oncology center I was at. I have been in remission for almost 3 years and my doctor says I am doing fine. It was not with out a lot of side effects ,but like you I would like to know why it is not used more .Ido know that there are alot of different types of NHL and it is not used for all kinds. I would not know how to advise anyone because I don't know how I would have been had I not received it. Iwould like to know what you decide and how you get along with it. Best to you      Carolyn    Dear Carolyn, Thanks for answering. Can you tell me what were your plaquets count when you had Bexxar. God bless you  Alejandrahe Mon, 31 Mar 2008 00:00:00 GMT I had a lot of hope in Bexxar.  I was sure it was going to give me a long remission.  At 3 months, no cancer.  At 6 months the cancer was back.  I am really disappointed.  They went to more chemo and radiation and then Rituxan.  Didn't take all the cancer away.  Now I am too weak and worn out and damaged that I can't have any therapy.  I will have a CT/scan in July, 6 months after the one that showed the cancer was still there.  Then they will know how fast it is growing and I will have a better chance at guessing how long I have left.Kitty-living what is the last of her 9 lives. GrammaKitty Mon, 31 Mar 2008 00:00:00 GMT  On 3/31/2008 GrammaKitty wrote:I had a lot of hope in Bexxar.  I was sure it was going to give me a long remission.  At 3 months, no cancer.  At 6 months the cancer was back.  I am really disappointed.  They went to more chemo and radiation and then Rituxan.  Didn't take all the cancer away.  Now I am too weak and worn out and damaged that I can't have any therapy.  I will have a CT/scan in July, 6 months after the one that showed the cancer was still there.  Then they will know how fast it is growing and I will have a better chance at guessing how long I have left.Kitty-living what is the last of her 9 lives.Dear Kitty, After the message I just reeived from Carolyne, I just not know what to think or do????Subject: RE: Why is not everyone using Bexxar?Date: 03/31/2008 On 3/28/2008 Alejandrahe wrote: I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡AlejandraI have also been wondering why more people have not received Bexxar .Ireceived it in May of 2005 after going through CHOP chemotherapy. Iwas on a clinical trial .The first  for the Oncology center I was at. I have been in remission for almost 3 years and my doctor says I am doing fine. It was not with out a lot of side effects ,but like you I would like to know why it is not used more .Ido know that there are alot of different types of NHL and it is not used for all kinds. I would not know how to advise anyone because I don't know how I would have been had I not received it. Iwould like to know what you decide and how you get along with it. Best to you      Carolyn  The doctors just want to go for RITUXAN again,  the latest reseach that I found is this¡¡¡Fatal Infusion Reactions: Deaths within 24 hours of RITUXAN infusion have been reported. These fatal reactions followed an infusion reaction complex, which included hypoxia, pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation, or cardiogenic shock. Approximately 80% of fatal infusion reactions occurred in association with the first infusionPatients who develop severe infusion reactions should have RITUXAN infusion discontinued and receive medical treatment.Tumor Lysis Syndrome (TLS): Acute renal failure requiring dialysis with instances of fatal outcome has been reported in the setting of TLS following treatment of non-Hodgkin's lymphoma (NHL) patients with RITUXAN. Severe Mucocutaneous Reactions: Severe mucocutaneous reactions, some with fatal outcome, have been reported in association with RITUXAN treatment.Progressive Multifocal Leukoencephalopathy (PML): JC virus infection resulting in PML and death has been reported in patients treated with Rituxan. PLease help¡¡¡MAY GOD BLESS  YOU ALL¡¡¡¡ Alejandrahe Mon, 31 Mar 2008 00:00:00 GMT I want to let know to everyone who responded my messages¡ and to everyone who will read it. life does not end after death. Don´t be afraid, just try to learn about cause and effect, and also try to learn about forgiveness, kindness and compassion. We will see each other again in after lifes if needed.  All my love, Alejandra   Alejandrahe Mon, 31 Mar 2008 00:00:00 GMT  On 3/31/2008 Alejandrahe wrote: On 3/31/2008 jucarthom wrote: On 3/28/2008 Alejandrahe wrote: I just can not understant why is not  almost everyone  should  be treated with Bexxar?All the reseach that I have done so far, leads me to Bexxar for a cure or for a list a very long term remission, without having to suffer the agony of  savage chemos, rituxan, hospitals and that all that involves for oneself and for the family.I am just giving some links to follow that I found on internetlymphoma.org/atf/cf/{0363CDD6-51B5-427B-BE48-E6AF871ACEC9}/BEXXAR.PDF http://www.patientadvocate.org/index.php? p=246http://www.lymphomainfo.net/therapy/immunotherapy/bexxar.htm Can somebody answer this? We are looking for the possibility of going for it, as all other treatments are not working at this point.God bless you all¡¡¡¡¡¡¡AlejandraI have also been wondering why more people have not received Bexxar .Ireceived it in May of 2005 after going through CHOP chemotherapy. Iwas on a clinical trial .The first  for the Oncology center I was at. I have been in remission for almost 3 years and my doctor says I am doing fine. It was not with out a lot of side effects ,but like you I would like to know why it is not used more .Ido know that there are alot of different types of NHL and it is not used for all kinds. I would not know how to advise anyone because I don't know how I would have been had I not received it. Iwould like to know what you decide and how you get along with it. Best to you      Carolyn    Dear Carolyn, Thanks for answering. Can you tell me what were your plaquets count when you had Bexxar. God bless you My platelet count got down to 28 after I received the Bexxar. Normal is 140 -440 . With the help of neupogen injections for a long time.they finally got to an acceptable number. They are now 128 which is still on the low side,but alot better. I know it is a hard decision to make but I would probably do it again.At the time a got it my oncologist told me had talked to an oncologist that specialized in this an was told she thought Bexxar was the magic -bullet for this type of NHL. Hope she is right. Time will tell. Hope you the best.   Carolyn   jucarthom Tue, 01 Apr 2008 00:00:00 GMT Bexxar is a great drug but its indication is for refractory follicular lymphoma.  Several studies have shown great promise as front line therapy, so I agree, it will soon be standard. Oncrx Thu, 03 Apr 2008 00:00:00 GMT Dear Carolyn,Would you please give me the contact details of you doctor?Warm regards, Alejandra Alejandrahe Thu, 10 Apr 2008 00:00:00 GMT I did have it and was one of the few it didn't work for.  My hopes were dashed. It was back in less than 6 months.  Kitty GrammaKitty Sun, 04 May 2008 00:00:00 GMT