CancerCompass message board discussion started by one4hope on 4/29/2008 http://www.cancercompass.com/message-board/message/all,23561,0.htm Mon, 01 Dec 2008 00:00:00 GMT Mon, 01 Dec 2008 00:00:00 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/ My son was diagnosed last May at the young age of 39 with Stage IV colon cancer.  He started on FolFox plus Avastin and after two treatments suffered a bowel perforation.  It was not thought that the Avastin was the actual cause of the perofration rather it was a tumor that necrosed and pulled away. Therefore, after two treatments the Avastin was restarted.  We were happy that his tumors were regressing.  After about six months, he developed significant neuropathy in his fingers and toes and the Oxaliplatin was stopped.  He remained on Leucovorin, 5FU and Avastin until last month when it was determined that his tumors were progressing.  He started Erbitux and Irenotecan last Monday and on Thursday suffered another bowel perforation.  Fortunately, they were able to find the perforation and repair it.  I am with him in the hospital waiting, hoping, and praying that his bowels will wake up and he can eventually restart treatment.  It is thought that the perofration was caused again by a tumor necrosing and pulling away.  He has multiple liver mets but unfortunately some peritineal seeding as well.  I am devasted by these new events and so afraid for him.  Has anybody experienced this?  Can anyone offer any hope?  I suspect the peritineal mets may be more of a problem that the liver mets. I don't post here offer because I feel I have little to offer anyone when I am so devasted most of the time or frantic to find something to cure my son or prolong his life.  I do read though of the brave battle that many of you are fighting.   If anyone can offer a bit of hope of inspiration, I can use it now.  God Bless all of you who are fighting the horrible, horrible disease.  one4hope Tue, 29 Apr 2008 00:00:00 GMT Hello,I have not had direct expirence with a 2nd bowel perforation but My husband is in the same age range as your son. My husband was diagnosed with stage 3 colon cancer at 35 and now is stage 4. My husband's cancer has spread to his stomach and surrounding scar tissue. He has had chemotherapy,radiation, surgery x2 and now is heading to Wake Forest to see if he is a candidate for debuking surgery and interpernerial chemotherapy....has anyone had this???? hope and prayers to all families who are deaing with these....is there a support group for 25-40 age group? Bleak Thu, 01 May 2008 00:00:00 GMT