CancerCompass message board discussion started by EvanS on 5/4/2008 http://www.cancercompass.com/message-board/message/all,23728,0.htm Thu, 20 Nov 2008 00:00:00 GMT Thu, 20 Nov 2008 00:00:00 GMT http://backend.userland.com/rss RSS.NET: http://www.rssdotnet.com/ My husband developed a neuroendocrine (small cell)prostate cancer, initially limited stage.He relapsed 4 months afterCDDP-VP-16 chemoradiation(etoposide+sisplatin). He now has bulky adenopathy and liver metsand he will be started on 2nd line chemo(carboplatin+topotecane).Does anybody know another therapy? A cancer medicine that called Avastin is recommented for this type of cancer?Thanks EvanS Sun, 04 May 2008 00:00:00 GMT  On 5/4/2008 EvanS wrote:My husband developed a neuroendocrine (small cell)prostate cancer, initially limited stage.He relapsed 4 months afterCDDP-VP-16 chemoradiation(etoposide+sisplatin). He now has bulky adenopathy and liver metsand he will be started on 2nd line chemo(carboplatin+topotecane).Does anybody know another therapy? A cancer medicine that called Avastin is recommented for this type of cancer?Thanks Hello, I am sorry this is happening to your husband. I just lost my father to this same disease 6 weeks ago. My father was diagnosed at age 71 with SCPC. At the time of his diagnosis, tumors were present on his liver, spine, ribs, shoulder and prostate. His initial treatment was etoposide+sisplatin. A follow up scan 8 weeks later showed no additional mets, however the existing tumors all increased in size. At that time his chemo switched to Taxol (Paclitaxel). He also started radiation to the prostate to deal with the extreem pain he was having there. After 3 additional weeks we had to stop all treatment due to his poor blood counts and a colon infection. Treatment for the infection took about 10 days. At that time he resumed the radation threapy. He contined with only radation threapy for another 4 weeks. A scan was done and showed numerous tumors in both sides of his brain. All cancer treatment was suspended and only comfort care was adminsistered. He died 5 days after. From the date he was diagnosed, he only survived 22 weeks.I spent many days reasearching this cancer and was unable to find any treatment that was associated with a favorable success rate. The advice I would offer is to be very cautious about radation threapy. I found a study that was done in mice that showed this type of cancer tended to spread much more quickly when radation threapy was done. My expereince with my father would seem to confirm that this does occure. Also, be very suspicious of any unusual behaviours or muscle spasiums. This can be side effects of the medications or it could be caused by tumors in the brain. A head scan is needed to be sure.Regards,James Nemanich     77Network Tue, 09 Sep 2008 00:00:00 GMT Hi,  I am the spouse of a man that has this form of prostate cancer. Is your husband responding to treatment? BEVVYGIRL Wed, 08 Oct 2008 00:00:00 GMT