Has any one tryed this Dr Red Blueberry Punch from Dr Red Nutraceuticals Pty Ltd), My doctor told me about it. I found some resurch on it, and it look very promising. (See the reults of the study on this page) this is from just one of the site in Austraila
http://www.usyd.edu.au/news/84.html?newsstoryid=2077
Antioxidant cocktail shows good results in fight against prostate cancer
7 December 2007
Prostate cancer trials undertaken at the University of Sydney have provided exciting results with reductions of up to 25 per cent of tumour growth in mouse models.
The trial of the commercially available antioxidant drink, Blueberry Punch, was undertaken by Dr Jas Sing from the University's ANZAC Research Institute and Dr Qihan Dong from the Bosch Institute, and will now to be put forward for human trials.
Blueberry Punch is an antioxidant cocktail based on foods which have been recognised as having similar attributes as non-steroidal anti-inflammatory drugs and their ability to inhibit a protein which puts the brakes on rapidly dividing cancer cells.
The Sydney University team studied the effect of the beverage on both cancer cell cultures and mouse models that mimic human prostate cancer with results published [online in the current issue of journal of the American Association of Cancer Research.]
'After 72 hours exposure to increasing concentrations of Blueberry Punch, prostate cancer cells showed a dose dependent reduction in size and viability when compared with untreated cells,' said Dr Sing. 'After feeding mice a 10 per cent solution of the punch for two weeks, we found the tumours in these mice were 25 per cent small than those found in mice that only drank tap water,' he said.
The study was partially funded by the makers of Blueberry Punch, Dr Red Nutraceuticals. The nutrition drink, Blueberry Punch, was developed by Greg Jardine, a biochemist from Dr Red.
Notes to Editors:
Blueberry Punch consists of a combination of fruit concentrates (blueberry, red grapes, raspberry and elderberry), grape seed and skin extract, citrus skin extracts, green tea extract (EGCG), olive leaf and olive pulp extract, tarragon, turmeric and ginger.
Contact: Jake O'Shaughnessy
Phone: +61 2 9351 4312 or 0421 617 861
| Anti-inflammatory Therapy: Poster Presentations - Proffered Abstracts |
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Suppressive effects of a phytochemical cocktail on prostate cancer growth
in vitro and
in vivoJas Singh, Mu Yao, Greg Jardine^ and Qihan Dong
Dept of Medicine, University of Sydney, Sydney, Australia, University of Sydney, Sydney, Australia, ^Dr Red Nutraceuticals, Mt Nebo, Queensland, Australia
Definition of In vitro (Latin: within the glass) refers to the technique of performing a given procedure in a controlled environment outside of a living organism, such as in a "test tube" or Petri dish.[1] Many experiments in cellular biology are conducted outside of organisms or cells; because the test conditions may not correspond to the conditions inside of the organism, this may lead to results that do not correspond to the situation that arises in a living organism. Consequently, such experimental results are often annotated with in vitro, in contradistinction with in vivo.
Definition of In vivo : In the living organism, as opposed to in vitro (in the laboratory).
Abstract A104
Inflammation is implicated in the etiology of prostate cancer (Etiology meaning in this case what Prostrate cancer could be cause by )
[1]. Evidence linking inflammation to prostate cancer includes men with chronic or recurrent inflammation of the prostate having an increased risk of developing prostate cancer
Cyokines is meaning in this case the Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialised glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
(12 Dec 1998)
http://www.mondofacto.com/facts/dictionary?cytokines
[2], over-expression of inflammatory cytokines in serum and prostate tissue of prostate cancer patients and a decreased prostate cancer risk in men on non-steroidal anti-inflammatory drugs. Numerous phytochemicals have been reported to interfere with specific stages of the carcinogenic process
[3]. Some of these phytochemicals like curcumin induces apoptosis (Apoptosis in this case meaning cell death) and cell cycle arrest in prostate cancer cells
[4] while Green tea has been shown to inhibit prostate cancer development and distant site metastasis in TRAMP mice (Means Prostate pathology genetically engineered mice)
[5]. Similarly, resveratrol has also been associated with inhibition of various cancers. Based on the premise that a wide range of phytochemicals in a single formulation are likely to demonstrate greater reduction in cancer cell proliferation than individual molecules administered alone, we investigated the in vitro and in vivo effects of an antioxidant cocktail, Blueberry Punch (BBP*; Dr Red Nutraceuticals Pty Ltd), that incorporates the above mentioned phytoconstituents, in prostate cancer.
>Cell viability studies undertaken using the MTS assay on prostate cancer cells (PC3, LNCaP) after 72 hours of exposure to increasing concentrations (0.08% - 5%) of BBP showed a dose-dependent reduction compared with untreated cells. This reduction in cell viability appeared around doses of 0.3%-0.6% BBP. Exposure of non-cancer prostate epithelial cells (PrEC) to similar concentrations demonstrated resistance of cells to BBP. Immunostaining of BBP treated cells indicated reduced COX-2 and phospho- cPLA2 protein levels. For in vivo studies, PC3 xenografts were created in immune-deficient nude Balb/C mice and treatment commenced when the tumors reached between 150-200mm³. Mice (n = 8) were administered BBP (10%) in drinking water for two weeks and tumor size and body weights monitored twice per week. At two weeks of treatment the tumor size decreased by 25% compared with mice (n = 8) that were administered regular tap water as control. Preliminary immunohistochemical analysis revealed decreased levels of Cyclin D1 protein suggesting reduced cell proliferation in BBP administered xenografts compared with vehicle treated mice. Our data provide evidence for in vitro and in vivo suppressive effects of BBP on prostate cancer cell growth. Further studies to determine the mechanistic pathways involved in the inhibition of cancer cell growth are in progress.
>1. Nelson et al (2003) NEJM, 349; 366-81
>2. Nelson et al (2004) J Urol, 172; S6-S12
>3. Surh YJ (2003) Nat Rev Cancer, 3; 768-780
>4. Khor et al (2006) Cancer Res, 66; 613-21
>5. Gupta (2001) PNAS, 98; 10350-10355
>* Antioxidant enriched fruit juice concentrate. Ingredients - Fruit juice concentrates (blueberry, red grapes, raspberry and elderberry), grape seed and skin extract, citrus skin extracts, green tea extract, olive leaf/olive pulp extracts, tarragon, turmeric and ginger.