Old Class of Drugs May Help Obese Breast Cancer Patients

by: cancercompass

Obese breast cancer patients could benefit from an older class of drugs called epithelial growth factor receptor inhibitors, which block stimulatory effects of hormones.

A study published in this month's Cancer Research said obese breast cancer patients produce more leptin, a hormone that is produced by fat cells and helps regulate appetite, bone formation and reproductive functions.

Leptin combined with heightened levels of insulin-like growth factor-1 (IGF-1) was shown by the study to stimulate breast cancer cell growth, reports ScienceDaily.

Researchers found that drugs inhibiting epithelial growth factor blocked the effects of leptin and IGF-1.  Study authors noted more tests in animal models is necessary to strengthen findings.