New Study Suggests Timing Plays Role in Dosing Chemo

by: cancercompass

Recent research conducted at the University of North Carolina (UNC) at Chapel Hill suggests timing plays an important role in dosing chemotherapy.

According to a UNC press release, Aziz Sancar, M.D., Ph.D and member of the UNC Lineberger Comprehensive Cancer Center and Sarah Graham Kenan professor of biochemistry and biophysics in the UNC School of Medicine, led a study to determine whether chemotherapy is more effective at certain times of day due to low levels in a specific enzyme system.

Researchers focused on the enzyme system called nucleotide excision repair, which can reverse the actions of chemotherapy drugs. Research findings suggest the best time to administer chemotherapy is when this enzyme system is depleted.

Sancar and colleagues studied mouse brain tissue to see when the system's ability to repair damage caused by chemotherapy was at its lowest levels. They found that the enzyme system was at its lowest working level in the morning and its highest level in the evening hours.

Though other studies have alluded to that same conclusion, the idea has been controversial for clinicians who don't think previous research has provided enough scientific explanation to back the idea.

This recent study was published in the Proceedings of the National Academy of Sciences.

Sancar says he wants to extend this study to mouse testis to see of the same applies to testicular cancer.