antiandrogen withdrawal ?

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antiandrogen withdrawal ?

by Helpforfather on Thu May 31, 2007 12:00 AM

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Hello, everyone!

I would like to ask readers' opinions and advice regarding the case of a 66 y. o.  diagnosed in 2003,  whose PSA started to rise recently. He was on flutamide since 2003 and also orchiectomy was peformed at that time. Now, in waiting for the bone scan and CT, his doctor wants him to directly start Casodex and stop flutamide. But I wonder whether or not he should have first tried the flutamide withdrawal alone for a while. I have read that prostate cancer cells might have mutated so that antiandrogens do in fact feed them instead of stopping them. To my mind, that means that stopping ANY antiandrogen for some time might make the cancer cells again responsive to hormonal treatment. My worry is that even if Casodex will induce a decrease of PSA for a while, the cancer cells will ultimately adapt to it too, and then the "hormonal weapon" is all but gone in the case of my father. On the other hand, I don't know if suspending the hormonal treatment while there is still Casodex that can be tried is not an even bigger mistake. So, I would much appreciate reading your thoughts and information you might have on the matter.

Many thanks and best wishes in good health and all other respects!

  

1 Posts | Page(s): 1 
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