Tg levels after RAI

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RE: Tg levels after RAI

by ToddlerFather on Tue Nov 06, 2018 03:47 PM

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On Nov 06, 2018 2:22 PM lcerrone wrote:

My endo is from Jersey Shore Medical in Neptune, NJ.  I wish that UPenn or Sloans would have something in NJ.  Sloan does but all the thyrod cancer specialist are in New York and its a little hard getting there.

I would think Boston is even harder to get to than NYC, but if not, MassGen's Dr. Lori Wirth would be an option I would consider:

https://www.massgeneral.org/doctors/doctor.aspx?id=17879

RE: Tg levels after RAI

by Andrea83 on Thu Nov 08, 2018 07:08 PM

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On Nov 05, 2018 10:12 PM butterfly501 wrote:

On Nov 04, 2018 6:15 PM lcerrone wrote:

I had RAI in April 2018.  In November 2017 my tg level was 11.8 however in July my level was 11.9. (stimulated tg before RAI was 25.7) Does this seem right that possibly my next labs will be going down??  

You had the I-131 ablation just 6/7 months ago?  Stimulated Tg is at 1 year post ablation.  That is what is recommeded in the professional guidelines. So, you still have some months to wait and see how the Tg is behaving.

What are the recommended guidelines? I just received my 1 year post TT and I131 ablation labs. I had them at 6 months post and I think my TG was 0.0. Now at 1 year post TT my TGAB is <0.9, TG is <0.1 and TG by lc-ms/ms was non applicable. Concerning because i was expecting 0.0. I had never even heard of TG by lc-ms/ms. Reading it sounds like these results would indicate negatives, but I still don’t even like seeing a 0.9.

RE: Tg levels after RAI

by butterfly501 on Thu Nov 08, 2018 10:30 PM

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lc-ms/ms is the assay that was used on the blood sample.  Your Tg is undetectable at <0.1 as that is as low as the assay can detect thyroglobulin. 

Rarely, if ever, are test results on blood specimens 0.0.  They all have a threshold as to how low they can detect thyroglobulin (or whatever).  TSH is the same.  When the result is < (less than) then that result is undetectable.  For thyroglobulin, that is a good thing.



RE: Tg levels after RAI

by butterfly501 on Thu Nov 08, 2018 10:35 PM

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Also, the same thing applies to the thyroglobulin antibodies.  The test can only measure down to 0.9, which is fine. 

When antibodies are present, a specific assay needs to be used to get an accurate Tg reading.  TgAb skews Tg results. 

If you don't have them (<0.9) then the assay used is not such a concern BUT the same assay by the same lab is recommeded for Tg measures.

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