Cediranib in Combination With Olaparib trial- is anyone trying this?

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Cediranib in Combination With Olaparib trial- is anyone trying this?

by Baloo on Tue Nov 20, 2018 04:51 PM

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I am signing up for a clinical trial that uses a combination of Olaparib  and Cediranib. It's at the Princess Margaret Hospital in Toronto. I have been through 24 folfirinox treatents and all I know about my cancer is that I've had a partial response to this regimen. I have not been able to find much information on these drugs. There seem to be quite a few simlar trials ongoing in the USA and I was hoping that someone is doing this, and can share their experience with it.

By the way here's a very good paper (2018) on new therapies: 

Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793409/

RE: Cediranib in Combination With Olaparib trial- is anyone trying this?

by caseyzson on Sun Nov 25, 2018 09:47 PM

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Hi Baloo I have been following your posts. My mother has stage 4 pancreatic cancer diagnosed 20 months ago. She’s going on her 5th line of therapy this week. When will you be starting the trial and how have you been doing?

RE: Cediranib in Combination With Olaparib trial- is anyone trying this?

by Baloo on Mon Nov 26, 2018 02:23 PM

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Hi caseyzson,

I did a bit of digging and have decided not to sign up for this trial. I do not know what mutations my cancer has, but it responded to folfifinox for a couple of years which makes me suspect that I have platinum sensitive BRCA mutations - but now folfirinox  has failed.The latest ct scans have shown that the main tumor has grown and now the lymph nodes around the tumor are enlarged and are getting bigger as well. This is considered metastasis. But I have not had another biopsy to confirm that it is actually the cancer, and not an inflammatory response, but the Ca 19-9 numbers are higher and  confirm cancer growth according to my doctor. 

As I understand it, Cediranib is a PARP inhibitor which can be effective on BRCA mutations, which also respond to platinum based drugs. But now that my cancer has become resistant to folfirinox I assume that the PARP inhibitor drugs will not work either and there's no point. 

I feel that, in hindsight, the folfirinox was given for too long a period before other treatments were tried. The nanoknife procedure should have been done earlier, when the tumor was smaller, and now that the folfirinox has actually failed.The PARP inhibitors will likely be useless too.

I've come to the conclusion that all these therapies are just delaying the inevitable and the only way to clean up this cancer is for my immune system to do it, which is highly unlikely due to the nature of pancreatic cancer and the two years of systemic poisoning by chemotherapy. So I''ve decided to focus on trying to rebuild my health, try alternatives in the likely- snake- oil but there's some evidence they have cancer fighting properties and won't hurt and might help category.  These are Rick simpson  oil, CBD oil, turmernic, coenzyme Q10, alpha lipoic acid, boswellia, mannitol, essiac tea( I really have no faith in this tea but I have it so might as well have a go! )   and try for some quality time. If nothing else trying all these will keep me busy and give me some faint hope.

Your mom has done exceptionally well, 20 months is very good and she has clearly giving the cancer a good fight. I hope that one of those therapies does the job! good

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