Hi caseyzson,
I did a bit of digging and have decided not to sign up for this trial. I do not know what mutations my cancer has, but it responded to folfifinox for a couple of years which makes me suspect that I have platinum sensitive BRCA mutations - but now folfirinox has failed.The latest ct scans have shown that the main tumor has grown and now the lymph nodes around the tumor are enlarged and are getting bigger as well. This is considered metastasis. But I have not had another biopsy to confirm that it is actually the cancer, and not an inflammatory response, but the Ca 19-9 numbers are higher and confirm cancer growth according to my doctor.
As I understand it, Cediranib is a PARP inhibitor which can be effective on BRCA mutations, which also respond to platinum based drugs. But now that my cancer has become resistant to folfirinox I assume that the PARP inhibitor drugs will not work either and there's no point.
I feel that, in hindsight, the folfirinox was given for too long a period before other treatments were tried. The nanoknife procedure should have been done earlier, when the tumor was smaller, and now that the folfirinox has actually failed.The PARP inhibitors will likely be useless too.
I've come to the conclusion that all these therapies are just delaying the inevitable and the only way to clean up this cancer is for my immune system to do it, which is highly unlikely due to the nature of pancreatic cancer and the two years of systemic poisoning by chemotherapy. So I''ve decided to focus on trying to rebuild my health, try alternatives in the likely- snake- oil but there's some evidence they have cancer fighting properties and won't hurt and might help category. These are Rick simpson oil, CBD oil, turmernic, coenzyme Q10, alpha lipoic acid, boswellia, mannitol, essiac tea( I really have no faith in this tea but I have it so might as well have a go! ) and try for some quality time. If nothing else trying all these will keep me busy and give me some faint hope.
Your mom has done exceptionally well, 20 months is very good and she has clearly giving the cancer a good fight. I hope that one of those therapies does the job! good