Terric, I will be starting abraxane/gemcitabine later this week, I figured, might as well try at least one of them. I sure hope it's no worse than the folfirinox.Being in Ontario, the protocol options available to me are extremely limited. I belive the third line therapy might be just straight 5-fluoro uracil, which I already received with the folfirinox, anyway. there's no mechanism to test my tumor to see which drug(s) from the folfirinox was (were) working, but I don't see why I would go back on that once it's already been ineffective. So this is probably it.
I did see some more information about that mannose/mouse study, someone responded on a forum who did the math and figured the mice were being given the human equivalent dose of 8 grams of mannose total per week ( fed 3x a week, not daily).But I have not read the actual research article myself or checked the math!
As far as I know people given 2 grams of mannose daily for 6 months for urinary tract infections suffered no serious consequences of the treatment. And I know of one golden retriever given 2 grams daily for urinary tract infections for over a year has had no (noticable)side effects. The dog has not had another urinary tract infection since.
Mannose seems pretty benign, but the researchers of course are cautioning people with cancer not to self medicate with mannose. I suppose that if ct scans are good and bloodwork is good, it would probably not hurt to continue with the mannose . Mannose does effect the gut microflora as well but it seems more beneficial than harmful.