Immunotherapy Trial and Car-T Cell Therapy

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Immunotherapy Trial and Car-T Cell Therapy

by superbowl52 on Tue Mar 19, 2019 10:50 AM

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Hello, 

Has anyone here been on the NIH Study (or other similar study) for immunotherapy + targeted therapy (nivolumab + cantozantinib)? If so, what kind of results did you have?

Also, have anyone here tried Car-T cell therapy for urachal? They are beginning to test it on a lot of different types of cancers with varying success. 

Would appreciate any feedback! 

Best to all

RE: Immunotherapy Trial and Car-T Cell Therapy

by DianaPB on Thu Mar 21, 2019 08:59 PM

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I am also interested in hearing any experience with nivolumab + cantozatinib trial.

Thanks.

RE: Immunotherapy Trial and Car-T Cell Therapy

by Clement on Thu Mar 21, 2019 11:07 PM

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Hello,

I have stage IV urachal cancer and this time last year, I was in a clinical trial for immunotherapy at Cedars-Sinai in Los Angeles, far from my home island.  I'm so glad the treatment was a success for many cancers, however it did not help reduce the size of my tumors. 

Sounds like you have been doing a lot of research.  I was first diagnosed in October of 2016 and have kind of lost interest in trying new things but I'm very interested in what you know.    

RE: Immunotherapy Trial and Car-T Cell Therapy

by superbowl52_ on Fri Mar 22, 2019 12:05 AM

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Do you know more specifically about what immunotherapy drugs you were on? Do you know if cabozantinib (or another targeted therapy) was also included in your trial?

Did your tumors stay the same size during the your time on the trial? If so, for how long? It sounds like a multi-month period of "Stable disease" is considered a reasonable "success" in these immunotherapy trials (which is better than disease progression but not the cure-all we would all like it to be.)

The Car-T cell therapy I mentioned is a very successful treatment for people with blood-based cancers that is only recently being test on solid tumor cancers (like uracahal, colorectal, pancreatic,etc). It is also called Adoptive Cell Transfer Therapy. There are a few trials at various institutions that might be open but we haven't actually tried to enroll yet. 

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