Myelofibrosis

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RE: Myelofibrosis

by jeff3 on Mon Jan 28, 2019 03:29 AM

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Thanks for the links. I read about inflammation in curetoday and I just learned about inflammation caused by senescent cells:

https://www.lifeextension.com/Magazine/2018/SS/Major-Advance

This effect on cell life is seen in red blood cells:

  https://europepmc.org/abstract/med/3052634

The impact of senescent cells in many health conditions can be found in the following:

https://www.sciencedirect.com/science/article/pii/S016372581

It's interesting that L-Carnosine can reactivate some senescent cells: 

https://www.ncbi.nlm.nih.gov/pubmed/21750159

and also inactivates  TGF-β

https://www.hindawi.com/journals/mi/2015/415024/

There are drugs the eliminate senescent cells and supplements such as Senolytic Activator taken once a week that L-Carnosine doesn't rejunivate.

Roger, I can't find another article I read that at least 30% of the cells in a enlarged spleen are senescent cells that the spleen can't clear. I guess the serrapeptase can't desolve them because they not dead, the're like zombies.

I hope your consultant can shed more light on senescent cells role in myelofibrosis. 

RE: Myelofibrosis

by Stimme on Mon Jan 28, 2019 10:17 AM

Quote | Reply

On Jan 28, 2019 3:29 AM jeff3 wrote:

Thanks for the links. I read about inflammation in curetoday and I just learned about inflammation caused by senescent cells:

https://www.lifeextension.com/Magazine/2018/SS/Major-Advance -in-Healthy-Longevity/Page-01"" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance

This effect on cell life is seen in red blood cells:

  https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634

The impact of senescent cells in many health conditions can be found in the following:

https://www.sciencedirect.com/science/article/pii/S016372581 830144X"" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581

It's interesting that L-Carnosine can reactivate some senescent cells: 

https://www.ncbi.nlm.nih.gov/pubmed/21750159 "" target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pubmed/21750159 " target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pubmed/21750159

and also inactivates  TGF-β

https://www.hindawi.com/journals/mi/2015/415024/ "" target="_blank" rel="nofollow">https://www.hindawi.com/journals/mi/2015/415024/ " target="_blank" rel="nofollow">https://www.hindawi.com/journals/mi/2015/415024/

There are drugs the eliminate senescent cells and supplements such as Senolytic Activator taken once a week that L-Carnosine doesn't rejunivate.

Roger, I can't find another article I read that at least 30% of the cells in a enlarged spleen are senescent cells that the spleen can't clear. I guess the serrapeptase can't desolve them because they not dead, the're like zombies.

I hope your consultant can shed more light on senescent cells role in myelofibrosis. 

Very interesting, Jeff, are you going to take quercetin and theaflavins?

Some of the other articles go over my head a bit but the first seems simple and straightforward ... can it be?

I will ask him!

Thanks for this. Will get back to you.

Roger

RE: Myelofibrosis

by Stimme on Wed Jan 30, 2019 03:58 PM

Quote | Reply

On Jan 28, 2019 10:17 AM Stimme wrote:

On Jan 28, 2019 3:29 AM jeff3 wrote:

Thanks for the links. I read about inflammation in curetoday and I just learned about inflammation caused by senescent cells:

https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance -in-Healthy-Longevity/Page-01"" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" rel="nofollow">https://www.lifeextension.com/Magazine/2018/SS/Major-Advance "" target="_blank" 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This effect on cell life is seen in red blood cells:

  https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 "" target="_blank" rel="nofollow">https://europepmc.org/abstract/med/3052634 " target="_blank" 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The impact of senescent cells in many health conditions can be found in the following:

https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 "" target="_blank" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S016372581 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It's interesting that L-Carnosine can reactivate some senescent cells: 

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and also inactivates  TGF-β

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There are drugs the eliminate senescent cells and supplements such as Senolytic Activator taken once a week that L-Carnosine doesn't rejunivate.

Roger, I can't find another article I read that at least 30% of the cells in a enlarged spleen are senescent cells that the spleen can't clear. I guess the serrapeptase can't desolve them because they not dead, the're like zombies.

I hope your consultant can shed more light on senescent cells role in myelofibrosis. 

Very interesting, Jeff, are you going to take quercetin and theaflavins?

Some of the other articles go over my head a bit but the first seems simple and straightforward ... can it be?

I will ask him!

Thanks for this. Will get back to you.

Roger

Hi, Jeff, and anyone listening in ...

I had my bloods done today and my consultant says some have improved, the others are stable! I don't really understand the figures though I do have the printout!

I have been more consistent with the supplements on my Herbalist's instructions. I have also added magnesium 1500mg to the Vit C, selenium 200mcg/vit E, Astaxanthin, Serrapeptase, Chaga mushroom capsules, tincture of nettle/artichoke/reishi and a multivit.

(Still no medications. In fact, I have not taken any since diagnosed early 2011!)

Meanwhile, Jeff, I asked him about senescent cells. He said MF isn't a case of dying cells it is a case of over proliferating cells.

Good hunting,

Roger

RE: Myelofibrosis

by jeff3 on Wed Jan 30, 2019 06:24 PM

Quote | Reply

Wendy, I too am excited and hopeful for ImMucin. This article from 2015 identifies it as an orphan drug so it appears to have FDA approval. This article seems to identify it as useful for MM. Myelofibrosis is not mentioned however the question needs to be raised with your doctor. 

 https://myelomabeacon.org/pr/2015/06/22/immucin-fda-orpha-dr

Actually Roger, the main role senescent cells play in myelofibrosis is contributing to inflammation which may be a factor to overproliferation. I hope he will take a second look at this. 

RE: Myelofibrosis

by jeff3 on Tue Feb 19, 2019 05:50 AM

Quote | Reply

There appears an inverse relation between Nitric oxide levels and bone marrow fibrosis. This article states Ruxolitinib (Jakafi) restores Nitric oxide level in bone marrow where myelofibrosis patients test low. Nitric oxide supplements like citrulline or beet juice powder and foods high in nitrates may offer a means to raise low bone marrow Nitric Oxide levels.

http://www.bloodjournal.org/content/124/21/4587?sso-checked=

https://www.mensjournal.com/food-drink/boost-sports-performa

RE: Myelofibrosis

by Stimme on Tue Feb 19, 2019 04:03 PM

Quote | Reply

Thanks for this Jeff. I can't get the second link - mensjournal but have sent the info to my Herbalist.

He is a pretty clever chap and is showing an interest in the condition.

RE: Myelofibrosis

by Lainela on Wed Apr 03, 2019 01:26 PM

Quote | Reply

Hi! 

Do sombody know something about herb Rhodiola Rosea? 

Here is some interesting information:

https://www.rainbow.coop/library/apoptosis-and-necrosis-with

https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid

Mabey it is worth to try it? 

Waiting for opinions.

RE: Myelofibrosis

by Stimme on Wed Apr 03, 2019 01:50 PM

Quote | Reply

On Apr 03, 2019 1:26 PM Lainela wrote:

Hi! 

Do sombody know something about herb Rhodiola Rosea? 

Here is some interesting information:

https://www.rainbow.coop/library/apoptosis-and-necrosis-with -rhodiola-rosea-in-cancer/?fbclid=IwAR1kb_092gCPgV3XEgKCjCoftN0FyLSonrdx-rUPHZjnnhBmWr0Hidoj7dE"" target="_blank" rel="nofollow">https://www.rainbow.coop/library/apoptosis-and-necrosis-with target="_blank" rel="nofollow">https://www.rainbow.coop/library/apoptosis-and-necrosis-with

https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid =IwAR2RdPmFxZxBFvGxqG_T9c5fo-kyZXVlHutT7kgTKkpfvlsveE_s_JUlWs0"" target="_blank" rel="nofollow">https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid target="_blank" rel="nofollow">https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid

Mabey it is worth to try it? 

Waiting for opinions.

Hi, Lainela,

I do have some and my Herbalist said, "Yes, good!" I have to admit That because I am taking so many supplements I have not been taking this! 

Maybe I should!

He also thoroughly approves the Serrapeptase (I use Serretia)

Honestly, I would advise getting a consultant in the Natural Health line. Chris, my Herbalist determines not just what is good but what is good for me! ASlso, since going to him I had an extra blood count improvement recently! 

Best wishes,

Roger

RE: Myelofibrosis

by Stimme on Thu Apr 04, 2019 10:12 AM

Quote | Reply

On Apr 03, 2019 1:26 PM Lainela wrote:

Hi! 

Do sombody know something about herb Rhodiola Rosea? 

Here is some interesting information:

https://www.rainbow.coop/library/apoptosis-and-necrosis-with -rhodiola-rosea-in-cancer/?fbclid=IwAR1kb_092gCPgV3XEgKCjCoftN0FyLSonrdx-rUPHZjnnhBmWr0Hidoj7dE"" target="_blank" rel="nofollow">https://www.rainbow.coop/library/apoptosis-and-necrosis-with target="_blank" rel="nofollow">https://www.rainbow.coop/library/apoptosis-and-necrosis-with

https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid =IwAR2RdPmFxZxBFvGxqG_T9c5fo-kyZXVlHutT7kgTKkpfvlsveE_s_JUlWs0"" target="_blank" rel="nofollow">https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid target="_blank" rel="nofollow">https://academic.oup.com/jrr/article/60/2/197/5193423?fbclid

Mabey it is worth to try it? 

Waiting for opinions.

I am having quite a lot of pain which could either be sciatica or bone pain or both. It is in arms, back and legs.

This article on cbd oil and leukaemia looks interesting...I do have some but my product purelife doesn't seem particularly effective. Does anyone know of a better make?

https://www.constancetherapeutics.com/learn-more/the-case-fo

Best wishes,

Roger

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