Myelofibrosis

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RE: Myelofibrosis

by Jri638a on Sat Mar 12, 2016 09:03 PM

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Hi Roland,

Welcome to the forum.

Vitamin C is the most important nutrition for your immune defense system!

For vitamin C the key word is abundance and that is hard to reach with acerola which has relatively small amount of vitamin C compared to the much more cost effective pure Ascorbic Acid (AA) or Sodium Ascorbate (SA). Vitamin C should to be most effective be consumed near to bowel tolerance level (BTL), see: http://vitamincfoundation.org/www.orthomed.com/titrate.htm

The most suitable form for oral consumption is Sodium Ascorbate since, as Roger also noted, Ascorbic Acid is to acid to be consumed over longer time.

When you mega dose vitamin C orally you have (in my opinion) only 3 variants to consider Ascorbic Acid (AA), sodium Ascorbate (SA) and homemade Liposomal Vitamin C (LipoC).

I personally have excluded homemade LipoC since effective cell absorption is not guaranteed/verified due to the large size of the liposomes compared to the liposomes in a factory made LC (I simply don’t want to risk it..). Factory made liposomes is most likely much smaller than homemade LC and even if homemade LC passes the stomach barrier, as a fat emulsion, cells may not be able to absorb the VC in the liposomes which in worst case makes it useless.

I have tried LivonLabs LipoC and I can actually feel the difference compared to homemade (1gr factory made lipoC gives a slight sense of wellbeing in my body whilst 5 gram homemade lipoC did not).  It may be that I'm worthless in making LipoC but it is hard to confirm quality of home made..

Factory made LipoC is rather expensive (approx 1 USD / gram) and I have excluded it for that reason alone even if it is more effective per gram. AA/SA is at higher volumes absorbed to 18-19% in blood whilst factory made LipoC is absorbed 5 times higher and it also lot easier gets absorbed through cell wall where AA has to first be reduced to dehydroascorbic acid to pass through cell wall and then back to AA once in the cell. Factory LipoC pass cell wall without any "cost".

If I had a more acute & critical condition I would go for factory made LipoC any day in the week.

Ascorbic Acid is in theory twice as effective as Sodium Ascorbate as a pure antioxidant having 2 electrons to donate whereas SA have only one (the free radical is neutralized when VC donates an electron to the free radical) which means the free radical don’t need to steal an electron from somewhere else i.e. from your DNA proteins).

In reality the bloods buffering system will likely buffer AA in blood (with bicarbonate/calcium) to SA since blood will always keep a ph. to 7,35-7,45.

AA is absorbed faster (through stomach wall) compared to SA (which is absorbed through gut) and AA gives a bit higher plasma level than AA but stays a bit shorter in blood.

Half-life of VC in blood is around 30 minutes; Half-life of VC in a glass of water in room temp is around 2 hours.

AA is, as Roger wrote, acidic and in long run not very practical to mega dose on since you need to compensate for the low ph or AA will draw calcium from your bones/teeth’s. AA is also (in long) run not so good for your teeth or throat. SA contains 11% bicarbonate and 89% AA (which is easily something you can mix @home, just be sure to buy bicarbonate and not baking powder which is not the same).

Note also AA/SA competes on cell absorption with glucose (through GLUT transport pathway) which means that you should prefer low sugar food to get best cell absorption of VC.

For me a normal day I consume 45-50 gr VC as AA/SA and when I'm not feeling well my BTL increases to 80-120gr which is a lot. As I get better I'm hoping my BTL will decrease.

Both AA and Bicarbonate can be bought rather cheap in powder form in larger quantities (I buy in 1 kg bags of both).

Best of health to you

BR Johnny

RE: Myelofibrosis

by schrol on Sat Mar 12, 2016 09:41 PM

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Thank you Johnny for your reply.

I am a bit confused as far a mixures are concerned if I understand properly you use

AA aprox 45-50 gr

Do you mix with Bicarbonate? which quantity?

How much water? what is the exact recepy/ mixture?

Do you drink the whole mixture at once?

Thank you in advance, sorry for asking so many questions

Roland

RE: Myelofibrosis

by Jri638a on Sat Mar 12, 2016 10:52 PM

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No worries, First: Level of consumption on VC is individual, read link in my prev post and you'll understand what is meant with bowel tolerance level (BTL). Your BTL will change with your health. A fully healthy person can usually only consume 8-15 gram on a daily basis before diarea, this can be useful to determine your health with. Bowel movements and frequent flatulence usually means you are closing in to your BTL. My 18 year old son can take 3gr of AA as tablets but if he take 4gr he is in trouble so by this he is rather healthy (if he takes 3gr 4 times a day this equals 12 gr in a day) When I have a cold I raise my BTL to approx double my normal BTL. To get sodium ascorbate containing 5 gr of vitamin C i mix a bit more than a teaspoon of ascorbic acid with a little bit less than a 10ml spice spoon in a glass of water (1.5 - 2 dl but water amount not very relevant). Mix/stir to powder resolved. (1 teaspoon = 50 ml and around 4.5 gr AA so a little bit more would be 5 gr of AA). Since half life of VC in blood is only around 30 minutes, fill upp every second to third hour or so if possible for best effect. Try to split intake evenly over day. Note that if you consume vit c in evening it may be hard to sleep until you're used to it. Start with lower amount and increase next day until you find your BTL. Note that approx 1 in 200 has a genetic defect that makes it impossible to take any larger amounts of vc so start with smaller amount first (its like being allergic to vc) Br Johnny

RE: Myelofibrosis

by jgard967 on Sun Mar 13, 2016 05:53 AM

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On Mar 12, 2016 8:23 PM schrol wrote:

Does anyone have any experience with the Japanese enzyme nattokinase?

It seems to be able to reverse adverse effects of fibrin.

http://www.newswithviews.com/Howenstine/james175.htm "" target="_blank" rel="nofollow">http://www.newswithviews.com/Howenstine/james175.htm " target="_blank" rel="nofollow">http://www.newswithviews.com/Howenstine/james175.htm

Any opinions obviously highly welcomed.

Roland

Please also look up SERRAPEPTASE as it can eat away any tissue such as scar tissue and it could help decrease scarring in bone marrow by the emzymes

https://serracor.wordpress.com

RE: Myelofibrosis

by Jri638a on Sun Mar 13, 2016 12:40 PM

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Correction: a teaspoon is 5 ml and a spice spoon is 1 ml.. BR Johnny

RE: Myelofibrosis

by jeff3 on Sun Mar 13, 2016 02:10 PM

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On Mar 12, 2016 8:23 PM schrol wrote:

Does anyone have any experience with the Japanese enzyme nattokinase?

It seems to be able to reverse adverse effects of fibrin.

http://www.newswithviews.com/Howenstine/james175.htm "" target="_blank" rel="nofollow">http://www.newswithviews.com/Howenstine/james175.htm " target="_blank" rel="nofollow">http://www.newswithviews.com/Howenstine/james175.htm

Any opinions obviously highly welcomed.

Roland

Roland, these links give an overview of enzymes and experiences in sports. I have been a user of systemic and digestive enzymes for over 15 years. One measure of their effect on me has been good health and when a required life insurance health examination was made for company executives, I was the only one rated "superior" and I was older than the others by ten years. No, I'm not an exercise role model. Minimizing cooking in food preparation preserves natural enzymes in food and takes the stress off the body to provide enzymes for digestion thus providing them for other needs. I think the roll systemic enzymes play in the fight against all cancers is important of course and their function in myelofibrosis is critical as they will allow the immune system to recognize these foreign bodies and the protocols access inside cancer cells to cause apoptosis and still dealing with scar formation. What's not to like?

http://www.livestrong.com/article/508661-3-specific-uses-of-

http://www.drdebe.com/articles/overcoming-athletic-injuries

http://www.dummies.com/how-to/content/how-do-enzymes-work-in

http://www.cancerfightingstrategies.com/enzymes-for-cancer.h

RE: Myelofibrosis

by Jri638a on Sun Mar 13, 2016 03:46 PM

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Hi Jeff, Enzymes seems like an area worth investigating further. From a first glance it does not seem to work so well with mega dosing of vitamin C: http://connersclinic.com/enzyme-therapy-and-cancer/ I'll have to investigate further when I have time.. /J

RE: Myelofibrosis

by ebyer on Mon Mar 14, 2016 03:35 AM

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On Mar 13, 2016 3:46 PM Jri638a wrote:

Hi Jeff, Enzymes seems like an area worth investigating further. From a first glance it does not seem to work so well with mega dosing of vitamin C: http://connersclinic.com/enzyme-therapy-and-cancer/ "" target="_blank" rel="nofollow">http://connersclinic.com/enzyme-therapy-and-cancer/ " target="_blank" rel="nofollow">http://connersclinic.com/enzyme-therapy-and-cancer/ I'll have to investigate further when I have time.. /J

I'm interested in researching the systemic enzymes as well. 

Someone mentioned telomerase...I'm curious what consolidated research says when focusing on MPNs. 

I was reading about clinical trials using Imelstat (pharma drug)...it's a telomerase inhibitor. as per studies, ppl with MPNs have telomeres that are too long. As per this, wouldn't an MPN patient want to avoid telomeres??? I'm still researching, so I'm not exactly clear on this topic. I do use curcumin (tumeric) w/black pepper extract. Many ppl have mentioned this supplement. 

https://ash.confex.com/ash/2014/webprogram/Paper74667.html

http://www.anti-agingfirewalls.com/2009/06/11/do-resveratrol

RE: protocol - I know Dalt mentioned a few ppl going into remission wi a few months. I've been using the protocol for about 6 months...nearly following it daily (at least 30g vit c, 4000mcg selenium)...I will have a BMB in the summer. I will post results/comparisons. 

Back to VIT C - I'm finding that my BT has significantly decreased. I used to be able to consume 30-40g of vit c...now I'm in the 20-30 range. Hoping this means I'm healing...

RE: Myelofibrosis

by schrol on Mon Mar 14, 2016 07:41 AM

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Has anyone tried to make liposomal Vitamine C by mixing lecithin and having it mix through an ultasonic unit?

Any experiences/ thoughts?

Roland

RE: Myelofibrosis

by Jri638a on Mon Mar 14, 2016 08:54 AM

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I bought an a bit more powerful ultrasonic cleaner and made Do-It-Yourself (DIY) lipo C a couple of times but since no sure way of asserting if it is generating liposomes small enough to penetrate cell walls (to my knowledge) I gave it up.

For me it is safer and a lot easier to just mix AA + bicarbonate in water compared to DIY lipo C.

Note also that higher amounts of lipoC may disturb your stomach causing your bowel tolerance level to be lowered (too much oily phospholipids in gut)

If you decide to go for DIY lipoC be sure to buy a more powerful cleaner to minimize risk of getting to big liposomes.
A good web site for DIY is: http://qualityliposomalc.com/

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