Small cell neuroendocrine prostate cancer

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Small cell neuroendocrine prostate cancer

by EvanS on Sun May 04, 2008 12:00 AM

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My husband developed a neuroendocrine (small cell)
prostate cancer, initially limited stage.He relapsed 4 months after
CDDP-VP-16 chemoradiation(etoposide+sisplatin). He now has bulky adenopathy and liver mets
and he will be started on 2nd line chemo(carboplatin+topotecane).Does anybody know another therapy? A cancer medicine that called Avastin is recommented for this type of cancer?Thanks

RE: Small cell neuroendocrine prostate cancer

by 77Network on Tue Sep 09, 2008 12:00 AM

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On 5/4/2008 EvanS wrote:

My husband developed a neuroendocrine (small cell)
prostate cancer, initially limited stage.He relapsed 4 months after
CDDP-VP-16 chemoradiation(etoposide+sisplatin). He now has bulky adenopathy and liver mets
and he will be started on 2nd line chemo(carboplatin+topotecane).Does anybody know another therapy? A cancer medicine that called Avastin is recommented for this type of cancer?Thanks

 

Hello, I am sorry this is happening to your husband. I just lost my father to this same disease 6 weeks ago. My father was diagnosed at age 71 with SCPC. At the time of his diagnosis, tumors were present on his liver, spine, ribs, shoulder and prostate. His initial treatment was etoposide+sisplatin. A follow up scan 8 weeks later showed no additional mets, however the existing tumors all increased in size. At that time his chemo switched to Taxol (Paclitaxel). He also started radiation to the prostate to deal with the extreem pain he was having there. After 3 additional weeks we had to stop all treatment due to his poor blood counts and a colon infection. Treatment for the infection took about 10 days. At that time he resumed the radation threapy. He contined with only radation threapy for another 4 weeks. A scan was done and showed numerous tumors in both sides of his brain. All cancer treatment was suspended and only comfort care was adminsistered. He died 5 days after. From the date he was diagnosed, he only survived 22 weeks.

I spent many days reasearching this cancer and was unable to find any treatment that was associated with a favorable success rate. The advice I would offer is to be very cautious about radation threapy. I found a study that was done in mice that showed this type of cancer tended to spread much more quickly when radation threapy was done. My expereince with my father would seem to confirm that this does occure. Also, be very suspicious of any unusual behaviours or muscle spasiums. This can be side effects of the medications or it could be caused by tumors in the brain. A head scan is needed to be sure.

Regards,

James Nemanich 

 

  

RE: Small cell neuroendocrine prostate cancer

by BEVVYGIRL on Wed Oct 08, 2008 12:00 AM

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Hi,  I am the spouse of a man that has this form of prostate cancer. Is your husband responding to treatment?

RE: Small cell neuroendocrine prostate cancer

by Pam1970 on Wed May 16, 2012 08:30 AM

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My husband also has this form of cancer. Anyone out there currently in treatment?

RE: Small cell neuroendocrine prostate cancer

by PatrickJ on Wed Jul 18, 2012 03:49 AM

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On May 16, 2012 8:30 AM Pam1970 wrote:

My husband also has this form of cancer. Anyone out there currently in treatment?

My wife was diagnosed with high-grade (small cell) neuroendocrine carcinoma. She has finished her 4th round of chemo and has done very well. They have had her on carboplatin and etoposide.

The cancer is likely to come back, but I have found several 2nd-line therapies online, plus a treatment in Europe called PRRT that is specific to neuroendocrine cancer. I'm going to try and get her in on that.

RE: Small cell neuroendocrine prostate cancer

by lastelling on Sun Jul 22, 2012 07:08 PM

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Hello

I was diagnosed with neuroendocrine cancer in my liver about 4 months ago. It was a complicated process that got me to that diagnosis so I won't go into that other than to say it is suspected that it started in my pancreas and has metastisized to my liver. I've never been told if it is considered small cell or large cell. Apparently my version of this cancer has the characteristics of both. My first round of chemo was with etoposide and carboplatin which did not work. Next we tried irinotecan and Gemzar but again no success. I'm currently doing what is known as FOLFIRI. It's a combination of irinotecan, 5-FU and some other stuff. We're doing this as a result of a process called Target Now molecular profiling of my cancer cells. The results of this chemo is not yet known as my next ct scan is still a few weeks away. If this also fails we will be giving my case over to an interventional radiologist who will try either Y-90 radioembolization or some form of chemo embolization directly into my liver.

Now, the interesting thing I've noticed is that for the past five of so years I've had an issue with BPH of my prostate. I've always had to get up at least 3 - 4 times per night to pee, often with discomfort. Since my second treatment in the FOLFIRI process this has all changed. My BPH seems to be gone and I pee like a young kid. The reason I mention this in this thread is that I've never been diagnosed with prostate cancer but no biopsies have ever been done either. The docs always used my PSA. Since it's always been below 2.0 they never went any further. I have an appointment with the oncologist tomorrow before my next FOLFIRI session and I wil bring this up to see what he thinks.

I hope sharing my problems can in some way help someone else.

Les  

RE: Small cell neuroendocrine prostate cancer

by Pam1970 on Mon Jul 23, 2012 02:57 AM

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Les, My husband had what he thought was BPH and he treated himself with antibiotics occasionally. He finally got to where he couldn't go at all and had to go to the ER to have a catheter put in. Next day he went to urologist and ended up having a turp. He was 48. The tissue from TURP came back adenocarcinoma and neuroendocrine prostate cancer. This was April of 2011. It had spread outside the prostate and to seminal vesicles and to a few nodes in the pelvis. So he had chemo first Adryomycin, cisplatin, etopiside. Three rounds and then had surgery. After surgery the path came back with 10 Gleason score still. So after some recovery he started radiation and did 36 days pelvis. He finished and CT was clear and then three weeks later he had another scan that showed 4 metastasis. Three in lung and one on adrenal gland. He then had 8 rounds of hard chemo. This time Taxol, etopiside and cisplatin. He then had clean scans. And Twi weeks started having back pain and headaches. He had brain MRI and LP and it showed lepto meningeal carcinatosis. This is NE small cell in the CSF around brain. Since chemo doesn't cross blood brain barrier this is why it happened. This was July 13 we found out an we went to his dr in Houston and he was started on steroids and has been on pain Meds. His dr started whole brain radiation and did an MRI of spine which turned out to have massive amounts of tumors like the csf did around brain. This may be the end for him. Only 1 year and three months from diagnosis. It is a horrible disease. I hope that you are able make sure cancer didn't start from prostate. I hope you are doing well with treatment an scans were clear. Pam

RE: Small cell neuroendocrine prostate cancer

by Pam1970 on Mon Jul 23, 2012 02:59 AM

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Hope she is doing well. Unfortunately my husband isn't.

RE: Small cell neuroendocrine prostate cancer

by TommyBrooklyn on Mon Sep 28, 2015 07:15 PM

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Aggressive Prostate Cancer with High Grade Neuroendocrine Differentiation

byTommyBrooklynon Mon Sep 28, 2015 03:04 PM

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Hi!  I am looking to meet people who have also been diagnosed with what my dad's prostate cancer has most recently morphed into; which is a "high grade neuroendocrine tumor."  He is presently undergoing a chemo combo of Cisplatin + Etoposide.   His cancer has spread from bones, into many lymph nodes, and outside the pleura of the left lung.

  I am very concerned hence there are so few people to discuss their stories with me regarding their past, present, and future treatments.

  Thanks!

RE: Small cell neuroendocrine prostate cancer

by Pam1970 on Mon Sep 28, 2015 09:56 PM

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So sorry to hear about your Dad. Unfortunately NE prostate cancer is rare and we had a hard time finding anyone with it at the same time. My husband was diagnosed with adenocarcinoma and NE prostate cancer at age 48. He had treatment for 13 months and passed away 14 months from diagnosis. If there is any questions I can answer I'll be happy to. He got wonderful treatment in Houston from Dr Amato. I wish your Dad the best Pam
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