5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

I'm new to this discussion. I've had two rounds of 5-FU. I am on a two week cycle. Supposed to get FOLFOX twelve times every two weeks w 48 hours of 5-FU on a pump. The first round I had bad mouth sores and GI upset. On day 12 I did my pre- chemo bloodwork and my neutrophils were only 300 so I a had a week delay in treatment. When I saw the PA Onc, she said they thought it was a fluke and they made no changes. Second round all my symptoms were lessened but come day 12, I'm neutropenic again and I have a week delay in treatment. Now they sent me for DPD testing. I'm considering refusing the 5-FU if the results aren't in by Thurs (my chemo day). But I'm kind of wondering- it see likely people that have the deficiency were seriously ill after the first dose. Should I be worried?? Maybe it's the Neulesta that isn't working?? Any thoughts are appreciated. Thanks

On Jun 16, 2013 1:39 PM BufJen wrote:

I'm new to this discussion. I've had two rounds of 5-FU. I am on a two week cycle. Supposed to get FOLFOX twelve times every two weeks w 48 hours of 5-FU on a pump. The first round I had bad mouth sores and GI upset. On day 12 I did my pre- chemo bloodwork and my neutrophils were only 300 so I a had a week delay in treatment. When I saw the PA Onc, she said they thought it was a fluke and they made no changes. Second round all my symptoms were lessened but come day 12, I'm neutropenic again and I have a week delay in treatment. Now they sent me for DPD testing. I'm considering refusing the 5-FU if the results aren't in by Thurs (my chemo day). But I'm kind of wondering- it see likely people that have the deficiency were seriously ill after the first dose. Should I be worried?? Maybe it's the Neulesta that isn't working?? Any thoughts are appreciated. Thanks

Dear BufJen 

(I'm BufJen, and new to this discussion. I've had two rounds of 5-FU. I am on a two week cycle. Supposed to get FOLFOX twelve times every two weeks w 48 hours of 5-FU on a pump. )

 

From Dave B on 5FU response, not FOLFOX?   I have a squamous carcinoma disease, a slow growth cancer caused by neurotoxin spider venom.  Therefore,  for my doctors did recommend and treat my rectal cancer in 2009, 2010 with 5-FU, a highly experimental / unproven drug.  5FU isfabricated in labs from extracts of spider venom.  For me it was like throwing gasoline on a fire, inflammation occured.  My sister Cathy had 5FU and did no good of any kind.  ( see 1,2,3 new treatement that did do good.)

My 5FU treatment application was also by pump, Porta-catheter inside chest ( the device is left abandon through to this day). It pumped 5-FU into my main neck artery into my heart, circulating to my body. The most intense saturation was my heart and lungs which have been 50% disabled, there is a dehydration of the lung / heart tissues. All of which, has cause much more damage. There was not one sign of recovery. The 5-FU made things worse, the radiation did some good on the spot verification. The doctors and nurses don’t know what they are doing in this chemo regard and trust only the 5-FU marketing promoters (copy text) who to this day have no great success stories. To the contrary, there are people who have used 5-FU cream with horrid results.

 IMHO, I would jump at the opportunity to support law suits against the makers and the treatment facilities who have used this reckless drug.  It was to be used only as a last resort drug and like me, it is a frist resort, applied without allergic dangers / testing evaluations.  The DPD testing is expensive but your insurance provider might cover it.  Without the test, do not take the drug, IMHO.(CancerCompass should start petition).

If your cancer comes (knowingly or unknowingly) from spider, wasp or bee venom, I highly recommend that a toxicologist review your lab work and apply proven treatment methodologies.

The Bartholomew cancers’:   Doctor’s discussion of Toxicology / Infectious Disease / Cancer Treatment

Spider Bites that started in 2007 ( now a Work Comp

case )   started 5 years ago, slow growth continues.

(b)    The  known venomization catagories and treatments for internal venomization illness / / necrosis neurotoxin / infectious disease? (not specific to hemotoxins, necrosis ).

1./       Hyperbaric Oxygen Medicine / Therapy    Susan Rodriguez C.H.T. identified the Hyperbaric Pressurized Oxygen Tank Treatment in combination with IV / proper medications.

2./       Drug / anti-venom treatment   IV drip:   injecting 1/10th CC of Dexamethasone (a cortisone, see internet)  Dexamethasoneananti-inflammatoryimmuno-suppressant.  When taken orally, it is 26.6 times more potent than the naturally occurringhormonecortisol and 6.6 times more potent thanprednisone.

3./      Surgery removal of all the offending slow growth cancer tumors.  (in other words, don't just zap the cancer, cut it out too.)

(c )    (background all research where venom may be cause of cancer cell multipling)  Have doctors verify lab pathology  ‘Spider Bite (Wasp, Bee) Venom’ as being the same as Slow Growth Squamous Cell Carcinoma Cancer. ( see Dave's 2008, 2009 Dr. Amster history,) The slow spread of cancer continues, despite the Work Comp cause of cancer, small slow growht cancer mounds increase with new insect bites.  There are many new active cancerous / venom mounds, now more than 10 mounds and spreading. The spreading is much faster now after most recent spider bite Jan. 3, 2013, including anal / sphincter cancer mounds returning.  

On Jun 16, 2013 1:39 PM BufJen wrote:

I'm new to this discussion. I've had two rounds of 5-FU. I am on a two week cycle. Supposed to get FOLFOX twelve times every two weeks w 48 hours of 5-FU on a pump. The first round I had bad mouth sores and GI upset. On day 12 I did my pre- chemo bloodwork and my neutrophils were only 300 so I a had a week delay in treatment. When I saw the PA Onc, she said they thought it was a fluke and they made no changes. Second round all my symptoms were lessened but come day 12, I'm neutropenic again and I have a week delay in treatment. Now they sent me for DPD testing. I'm considering refusing the 5-FU if the results aren't in by Thurs (my chemo day). But I'm kind of wondering- it see likely people that have the deficiency were seriously ill after the first dose. Should I be worried?? Maybe it's the Neulesta that isn't working?? Any thoughts are appreciated. Thanks

Please wait for the results. I am glad to hear they are testing you, hopefully that is an indication the medical community more aware of this deficiency. I strongly believe everyone should be tested before starting 5FU, and pray one day it will be the "standard of care" to test prior to starting treatment. I hope the test does not show a deficiency, but if it does do not take any more treatments of 5FU. Good luck with your treatments, and feel free to contact me through this site if you have any questions.

On Jun 21, 2013 7:47 AM Maryl wrote:

On Jun 16, 2013 1:39 PM BufJen wrote:

I'm new to this discussion. I've had two rounds of 5-FU. I am on a two week cycle. Supposed to get FOLFOX twelve times every two weeks w 48 hours of 5-FU on a pump. The first round I had bad mouth sores and GI upset. On day 12 I did my pre- chemo bloodwork and my neutrophils were only 300 so I a had a week delay in treatment. When I saw the PA Onc, she said they thought it was a fluke and they made no changes. Second round all my symptoms were lessened but come day 12, I'm neutropenic again and I have a week delay in treatment. Now they sent me for DPD testing. I'm considering refusing the 5-FU if the results aren't in by Thurs (my chemo day). But I'm kind of wondering- it see likely people that have the deficiency were seriously ill after the first dose. Should I be worried?? Maybe it's the Neulesta that isn't working?? Any thoughts are appreciated. Thanks

Please wait for the results. I am glad to hear they are testing you, hopefully that is an indication the medical community more aware of this deficiency. I strongly believe everyone should be tested before starting 5FU, and pray one day it will be the "standard of care" to test prior to starting treatment. I hope the test does not show a deficiency, but if it does do not take any more treatments of 5FU. Good luck with your treatments, and feel free to contact me through this site if you have any questions.

Thank you so much for ur support. Luckily my test results were in prior to treatment and I am negative. Although there is quite a disclaimer that the test is not all knowing. So I saw Onc and he said they will reduce my dose by 25% and see how that goes. Maybe my body is responding to Neulasta. But they are giving that another go as well. I did purchase The Moss report on colon cancer and after this I re-read the section on 5 FU and he doesn't mention this gene at all. I agree it should be standard testing. First, do no harm. Correct? Best wishes everyone.

To BufJen and Maryl

If not for Cancer Compass ... where would we be? I have not found another discussion site that functions this well.  For far too many of us, the cancer sets in, our brains are typically not sharp enough to find anothermore applicable,more specific on targetinternet discussion site. THEREFORE I must apologize for abruptness, assumptions, grave statements.

PRAYER:    I wish there was a more applicable site to my ‘squamous carcinoma cancer growth’ that is a direct result of ‘recluse spider and black widow spider’.  (Sorry.  I realize that just one spider can cause the onset of  renal / rectal / heart failures. Working as a night security guard has its high percentage of interaction with the night crawlers.  So sorry to BufJen – to assume we know where your cancer comes from.  THEREFORE:   My prayer would be answered if the Compass would point the way (for us all) to appropriate specific applicable treatment as my prior post identifies.  Not this crappy 5FU marketing trick drug.

All my life, I gave 110% to raising three daughters,  giving to a wife who wanted more and could spend 120% take home from the two jobs (very hard work)  I had built up after college education (1978), teaching, commercial art commissions.  I could find ways to blame NAFTA, my parents, my regrets.  But, please know of my silver lining, on the bright side I will see my first granddaughter being born in Philadelphia, PA this week,  all the way across country.  Thanks to SKYP,  internet.  Nicole is just one of three practically perfect daughters as Mary Poppins would measure them. PRAYER answered.  Dave.  

Hi my mother was diagnoised with appendix cancer in March/ She had 3 5FU treatments at full dosage of 500mg and 1 at 20% reduced. She had gotten very sick. Diarrhea uncontrolled, extream weakness and would not eat or drink. Finally, I had her admitted for dehydration. They said she had colitis, put her a strict diet and 2.5 weeks later said she never had colitis. Her doctor has said all along it was a percaution to do Chem as the scans are clear. They after the toxcitiy of 5FU he said she could never have Chem again and should get radiation as she has an enzyme deficiency. Which they never told the enzyme that was deficient. However, if the scans are clear there is nothing to radiate. We are now at a Medical School where they specialise in this cancer as there is a 1% chance of getting it. The doctor called last Friday and said he did not agree with the new doctor.  It has been very stressful over the last 4 months. 

Mary I will keep you in my prayers and and thank you for sharing.,

Mary said, “with appendix cancer”  Response:  What size? IMHO, doctors should have cut it all out, immediately!”

Mary said, “She had 3 5FU treatments” 

Response: OMG! For what? Background, to look up. “5FU” is toxic poison, first fabricated from extract spider venom molecules/DNA, by immoral scientists, rushing an unproven product by profiteering labs to gain business with people near dearth, scared to death without choices … instead, you had many choices. 

Mary said, “Diarrhea uncontrolled, extreme weakness”  

Response:  They claim the toxicity of the 5FU eventually flushes out, but I am in my 5th year,  the 5FU still dehydrates my heart, chest, left shoulder – it grows more devastating, not less.  My doctors chose Chemo-Radiation to treat my Black Widow / Recluse Spider bite ‘Anaphylaxis Systemic Toxins (poisons) in my body’  The main side effect impact is extreme weakness.  Diarrhea becomes a life problem now, almost impossible to recover from without expert dietician.  Good luck.

Mary said, “enzyme deficiency” problem. 

Response:   This area of health is currently (or should be) the worlds No.1 research category, for it entails the functioning of your metabolism, creating energy, fat burning catalysts, combating fatigue releated diseases, empowering white blood cell defense systems; all of which can make you stronger, to recover, to regain youthful exuberance, etc.  For COMBATING SYSTEMIC DISEASE: Plus, it is God’s tools most doctors do not yet know how to engage with synergy treatment plans.  So, consider making your treatment plan for sadly doctors will not do this for you, in doing so, ( sins of omissions )  prolong their own profiteering (obvious corruption of our national health care system in every facility admin ). 

Response proposal:      Rush to treatment, if applicable, if funded  (1) The surgery, for doctors often say ‘no surgery’ for none polyp conditions. We must do our own diligence to help the doctor define terms, what is operable, what is not?  (2) The steroid-cortisone antibacterial targeted medicines are very important ( never use 5FU, anyone, anywhere IMHO ), Use proven steroid-cortisone mixes on IV delivery, while at the same time, a long term plan for saline solution IV to reverse dehydration while during this long term process  (3) Use the Hyperbaric Chamber to re Oxygenate your body all cells, (4)  The use of lymph-a-suction to removediseased lymphatic cellulitis  in your gut, chest, buttocks, etc.   GOOD LUCK … Dave B.

I absolutely would wait for the results to the test.  I was affected by the first dose, however it took 17-days before I was critically ill.  The symtoms are the same as the side effects you expect from the chemo, however they continue to worsen rather than improve.  If you do have the deficiency it could kill you. The fact that they are testing you, implies to me, they feel you may have the deficiency. Please wait for the results. 

God Bless

I had flu like symptoms from my first application on the 11 day I ended up in the hospital toxic reaction hives swollen lips joints esauphagus plus more. I do have permanent side effects overall loss of endurance muscle pain weakness and muscle loss in my thighs the largest muscle in our body. Prior to the toxic reaction I was perfectly healthy!! It took me over 2 years to get my immune system to where I was not sick all the time. I go in for blood work every 6 months due to problems from the reaction!

On Aug 17, 2014 5:20 PM nelsonterry wrote:

I had flu like symptoms from my first application on the 11 day I ended up in the hospital toxic reaction hives swollen lips joints esauphagus plus more. I do have permanent side effects overall loss of endurance muscle pain weakness and muscle loss in my thighs the largest muscle in our body. Prior to the toxic reaction I was perfectly healthy!! It took me over 2 years to get my immune system to where I was not sick all the time. I go in for blood work every 6 months due to problems from the reaction!

Hi Nelson Terry

So:  Please complete "inbetween the lines" stuff.  Am I correct to say, you were given 5FU / Chemo Drug?  Is it, because you had "the Flu"  or because you were diagnosed with cancer? (What kind?) 

My side effects are similar to yours, but my immune system, my metabolism has not recovered.  I have overlapping Industrial Illness; Black Widow bite, other insects and House Centipedes I once thought was not dangerous. 

I would like my doctors to treat me with 4 step process, but they refuse.  Did you know 5FU is made from 1960's scientists messin' with spider venom / resulting new (deadly) product.   Thanks so much for your Dpd Enzyme Test results. How much did the test cost? Was it covered under you Health Plan.  Should it be covered under a Work Comp Health Plan?   

DaveBartholomew at cox dot net