Solvestrols at work

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RE: Salvestrol

by AJoan on Fri Mar 22, 2013 01:04 PM

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On Mar 22, 2013 11:16 AM bigsky20 wrote:

Sorry about the copy of the extra long quote. It seems as if we quote the same post with links over and over, it gets longer and longer. It slightly annoys me!

Wonderful find Kami. Thank you. I'm jumping on it. It can save lives, not just my own. Already put my doctor on it.

Kami, you need to get a job with Gerry.

Can Salvestrols work in 100% of people?

by swift on Fri Mar 22, 2013 08:59 PM

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Hi all,

I'd like to thank you all for sharing your findings and especially to Bigsky20 (i.e. Kami), from whom I've learned a lot lately based on the links provided in recent posts.  

And to Macdon, who also posted two interesting questions recently that I'd like to answer.
 
To quote Macdon:

1. "I think we should get back on track and find out how to make salvestrols work in 100% of people. That is, can we find supplements to help with the malfunctioning cytochrome P450 enzymes?"

2. "Could enzymes assist salvestrols in being effective for more people, bearing in mind that enzyme therapy is a purported cancer cure in itself?" 

Here are my observations: 

  Note that CYP1B1 is a cytochrome P450 enzyme that is directly involved in the efficacy of Salvestrols. Salvestrols require CYP1B1 to work. It is a fact that high doses of Resveratrol (50 mg), exposure to cigarette smoke and B17 inhibit CYP1B1. There may be other inhibitors or substances that inhibit or deactivate the CYP1B1 enzyme. In case you didn't know, Tamoxifen has been known to inhibit CYP1B1 but I won't discuss this issue here. 

  From what I've read about Salvestrols, I've found that Salvestrols may be rendered ineffective in at least two ways:

1. When there is no CYP1B1 protein in cancer cells, or
2. When there is CYP1B1 protein in cancer cells but there is a malfunction in the glucuronidation process in the body.

Here are my answers and suggestions to Macdon's questions. The following numbers correspond to the two questions asked: 

1. It is a fact that almost all cancer cells have the overexpression of CYP1B1 protein. Emphasis on "almost", i.e 96%, according to Dan Burke. Malnutrition may be remedied by taking more of the amounts required for the co-factors of CYP1B1 such as Biotin, Niacin, and a little Iron (note: an overdose of Iron is harmful and Iron supplements may not be required since most of us get enough in our diets) and perhaps also Magnesium, since the later is involved in the metabolism of enzymes in general. Also consider taking trace minerals and B complex supplements that provide a full range of B vitamins and their co-factors. Those with genetic mutations in the CYP1B1 gene may still have this issue unresolved even after taking such supplements.

So consider the following ingredients, in case they may be missing or deficient.

Trace minerals: 

http://tinyurl.com/d9lgm9d

 Quote: "Research on trace minerals has demonstrated their importance in human health. Trace minerals are cofactors for most enzymes in the body and are essential for proper hormone and neurotransmitter function. Deficiencies of specific trace minerals can have an adverse impact on cardiovascular health, bone health, fertility, cognitive health, and immunity. Even mild deficiencies in trace minerals can result in poor growth and development. Many dietary trace minerals are found in fruits and vegetables; however, mineral depletion of the soil has rendered much of the produce we buy deficient in these essential nutrients. Because of these circumstances, supplementation may be indicated. 

Zinc (as Zinc Picolinate)   15 mg.
Selenium (as Selenium Picolinate)   100 mcg.
Manganese (as Manganese Picolinate)   2.5 mg.
Chromium (as Chromium Chelidamate Arginate)   100 mcg.
Molybdenum (as Molybdenum Picolinate)   50 mcg.
Boron (as Boron Picolinate)   700 mcg.
Vanadium (as Vanadium Picolinate)   50 mcg.

B complex supplement: 
http://tinyurl.com/bpoukz7

  "Supplementing with active B vitamins is extremely important to everyone, especially individuals who may not be able to convert non-active vitamins to their active forms in the liver because of compromised liver function, poorly functioning enzymes, digestive disturbances, or age. Dietary supplements containing these active cofactors have enhanced bioavailability, ensuring the body gets the nutrients it needs.

Thiamin (as Thiamin HCl) 110 mg.
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 10 mg.
Niacin (130 mg as Niacinamide and 10 mg as Niacin) 140 mg.
Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg.
Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 400 mcg.
Vitamin B12 (as Methylcobalamin) 400 mcg.
Biotin 400 mcg.
Pantothenic Acid (as Calcium Pantothenate) 110 mg.
Choline Citrate 80 mg."

Magnesium supplement: 
http://tinyurl.com/d8m48b5


  "Magnesium is one of the body’s most important minerals. It is required as a cofactor in hundreds of enzymatic processes within cells.

Magnesium (as magnesium oxide, aspartate, citrate, succinate, TRAACS® magnesium lysyl glycinate chelate) 500 mg" 
  
2. To ensure the glucuronidation process in the body, thereby rendering the Salvestrols effective, consider taking a supplement called Calcium D-glucarate.
It is available here: 

http://tinyurl.com/bacs5zj

  "Calcium (from Calcium D-Glucarate) 24 mg
Calcium D-Glucarate 200 mg
 
D-glucarate is found in grapefruit, apples, oranges, broccoli, and Brussels sprouts. D-glucarate supports the body’s cleansing system — a detoxification mechanism called glucuronidation. The human body uses glucuronidation to make a large variety of substances more water-soluble, and, in this way, allow for their subsequent elimination from the body through urine or faeces (via bile from the liver)."

To be continued in my next post..

Regards, Swift

RE: Can Salvestrols work in 100% of people?

by bigsky20 on Fri Mar 22, 2013 10:01 PM

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Swift,

I think I love you, lol! Thank you for answering our questions in such great detail!

I take trace minerals and the brand that I buy is Optimally Organic Fulvic ionic minerals. It contains over 77 trace minerals and essential amino acids. I also take transdermal magnesium.

Here is some info on the Fulvic Acid site:

Fulvic Ionic Minerals can both balance and energize cell life and biological properties once it comes into contact with the cell. If the individual cell is restored to its normal chemical balance and electrical potential, we have given the cell life where death and disintegration would normally occur. This is due to the ability of Humic Acid to break down the salt acids that build up on the cell membrane, and the ability of Fulvic Acid to transport nutrients into the cell and flush toxins out of the cell. Fulvic and Humic Acids will break the bonds of inorganic matter and transform them into organic matter, including radiation and petroleum, and remove them from the body.

http://www.optimallyorganic.net/products/fulvic-ionic-minera

Kami

 

RE: Can Salvestrols work in 100% of people?

by bigsky20 on Sat Mar 23, 2013 03:31 AM

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Swift,

This sentence that you wrote intrigued me:

"When there is CYP1B1 protein in cancer cells but there is a malfunction in the glucuronidation process in the body."

I found this:

Glucuronidation plays many roles in the body, not just that of binding estrogen, thus one may have low or normal levels of glucaronic acid along with low, normal or high levels of estrogen. The healthy body employs many different detoxification pathways, in the liver and elsewhere, of which glucuronidation is one. Glucuronidation removes several toxic and potentially toxic chemicals from our system, such as polycyclic aromatic hydrocarbons, steroid hormones, some nitrosamines, heterocyclic amines, some fungal toxins, and aromatic amines. It also removes "used" hormones, such as estrogen and T4, that are produced naturally by the body. This, glucuronidation represents a major means of converting most drugs, steroids, and many toxic and endogenous substances to metabolites that can then be excreted into the urine or bile.

The liver, spleen, and gut may be damaged or otherwise impaired by several means:

  • Liver disease or disorder, such as hepatitis
  • Drugs or toxic exposure disrupts phase 1 or phase 2 function
  • Accidental ingestion of toxic substances (such as plants, poisons, drug overdose, mercury)Intentional ingestion of substances which overload detox pathways (such as nicotine, acetaminophen, NSAIDs, xenobiotics, therapeutic glycosides, etc.

Many of these toxic and otherwise therapeutic substances (xenobiotics, drugs) disrupt the glucuronidation by impairing it, stopping it, or causing the binds to be rupture, separating the bound molecules from its inert transport. The toxins that are thus not removed by normal binding and excretion may settle elsewhere in the body, causing tumors and other signs of toxicity.

Glucuronidase is an enzyme that inhibits the glucuronidation process, breaking apart the bound toxins. Calcium D-glucarate(a calcium salt that is found in some plants, such as apples, grapefruit, broccoli and alfalfa) suppresses that enzyme, restoring this particular detoxification pathway. A benefical fungus, Saccharomyces boulardii, helps reduce some of the gut organisms that produce glucuronidase."

http://tinyurl.com/bgs7uwb

I believe that my body is full of toxins. I was told that my liver isn't in the best shape and I don't even drink alcohol. I have been exposed to a zillion pesticides from a crop plane that flew over my house.

I have estrogen positive cancer and the levels are very high so maybe glucuronidation isn't binding estrogen in my body.

Anyway, I'm going to make sure that I take calcium d glucarate now. I have a bottle that is just sitting on my counter and I haven't given it much importance. I just love the way this thread is going, I'm learning so much.

Thank you everyone!!

 

RE: Can Salvestrols work in 100% of people?

by bigsky20 on Sat Mar 23, 2013 03:49 AM

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Ok, I remember why I stopped taking calcium d glucarate. I read that it might interfere with tamoxifen. Is that true?

RE: Can Salvestrols work in 100% of people?

by calin on Sat Mar 23, 2013 02:52 PM

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I am enjoying this discussion!

Good job Swift and all!

Most vitamin supplements have those ingredients Swift mentioned. At least mine does!

I also rub magnesium chloride oil on my body daily. Transdermal magnesium oil gets 100% absorption and none of the laxitive effects. However I do ingest a magnesium citrate powder in my health drink as well.

RE: Can Salvestrols work in 100% of people?

by calin on Sat Mar 23, 2013 05:46 PM

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Dear Swift,

I have been hunting all over the place for a link or resouce to your above comment: 1. It is a fact that almost all cancer cells have the overexpression of CYP1B1 protein. Emphasis on "almost", i.e 96%, according to Dan Burke.

Could you be so kind as to provide a link or resource paper  that indicates the 96% factor said By Prof. Burke, please? I am going nuts trying to find that percentage.

I read the book "Salvestrols: Nature's Defence Against Cancer: Linking Diet and Cancer" by Dr. Brian Schaefer.

On page 48, title "Levels of CYP1B1Expression",  there is no percentage listed. Just that there are degrees of expression in different cancers and people and that it is based on the induction pathways of CYP1B1 (processes that lead to the production of CYP1B1).

The author states that to insure increased production, take biotin (vitamin H) - the RDA is fine. This recommendation is the same everywhere regarding salvestrols.

Has anyone read the book? Great reading and very encouraging!


RE: Can Salvestrols work in 100% of people?

by swift on Sat Mar 23, 2013 10:51 PM

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Hi all,

Researchers have shown that CYP1B1 was not detected in all cancer samples and yet all cancer types have CYP1B1 expression. This statement may seem contradictory so I shall provide an explanation here along with links and quotes from resources. By reading this, I hope that it helps you to obtain clarity on this issue.

To quote Calin:

"Could you be so kind as to provide a link or resource paper that indicates the 96% factor said By Prof. Burke, please? I am going nuts trying to find that percentage." 

Here is an excerpt of a paper by the CYP1B1 expert Professor Dan Burke. The title is "Evidence that CYP1B1 is a Universal Tumour Marker"

For the complete article please go to: 
http://tinyurl.com/d8zqe2m 
 
Notice the various percentages that are listed in the paper,

The CYP1B1 was detected in:

96% of cancers samples from different types,

77% and 82% of breast cancer samples,

92% of ovarian cancer samples, 

100% of bladder carcinoma, 

75% of prostate carcinoma samples, 

79% of prostate cancer samples, and

61% and 84% glial cell cancer samples.

Also in the page 47 of the book "Salvestrols: Nature's Defence Against Cancer: Linking Diet and Cancer" by Dr. Brian Schaefer: "CYP1B1 has been found to be present in the malignant cells of 98% of mesothelioma cases studied, and in abundance, much as is seen in ovarian cancers."

Furthermore, please refer to this link to a research paper regarding CYP1B1 published in 2006. 
http://tinyurl.com/d6k6r4r

  On the page labelled 138, "Table 1. CYP1B1 Tissue-Specific Expression in Hormone-Mediated Cancers and Corresponding Normal Tissue", the table shows that not all cancer samples tested had detectable levels of CYP1B1.

After reading the article by Dan Burke, here are my observations with quotes from the article.

Initially, Dan Burke's research team tested most types of cancer: "A total of 127 different cancer patients were sampled, with between 6 and 12 patients per cancer type, and CYP1B1 was expressed in 96% of the samples and in all the different types of cancer. " This statement did not include all types of cancer, as you may recall this reference to slide 6 in his presentation. Here is the link to the presentation:http://tinyurl.com/bnsn8dt

  When all types of cancer were tested in subsequent research, as shown in slide 8 of that presentation by Dan Burke, it was found that all cancer types had CYP1B1.

  In the article, it was generally accepted that CYP1B1 is: “a shared-tumour associated antigen expressed in almost all human malignancies tested so far”. Note the emphasis on "almost all", which refers to the percentage of cancer samples, i.e. almost 100% (or 96% according to Dan Burke) of cancer samples tested that had CYP1B1 in their cancers.

To summarise:

 The terms "96%" of cancer samples have CYP1B1 and "all cancer" types have CYP1B1 can be used together in a non-contradictory manner as they refer to essentially two different aspects: cancer samples and cancer types.

 That is all I have to comment on this issue. Thank you for your kind attention! :)

Regards, Swift.

RE: Can Salvestrols work in 100% of people?

by calin on Sun Mar 24, 2013 03:08 AM

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I appreciate the detail and references.

I see in Dr. Schaefer's book dated 2012, he indicates that differences in the expression level may be due to differences in the laboratory methods for detecting and measuring CYP1B1 levels.

RE: Can Salvestrols work in 100% of people?

by AJoan on Sun Mar 24, 2013 03:11 PM

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Thank you all, for the excellent information and references.

I copied it for myself and also for my doctor, who is very interested in patient feedback.  I need to read all of it carefully, and absorb it.

Read somewhere in one of Gerry Potters comments that he recommends Reiki for cancer patients. Don't know where I read it, but it's in there somewhere.

Also, I've been learning from Donna Eden about clearing the auric field: cleansing auras, chakras, meridians, and energy fields.

http://innersource.net/em/about/donna-eden.html

Eden is one of the best at what she does. On her site, you can find certified practitioners in the country or region where you live.

We're more than just the physical bodies that we can see with bare eyes. Some of us can actually see auras, however.

If you can't see your aura, you'll be able to feel it. Much healing takes place in your aura. Your physical body follows suit.

Also, you want to clear your lymphatic system regularly.

If you've had surgery and radiation, I can almost guarantee that your lyphatic system is sludgy where you had the radiation. So you'll need to help yourself to get rid of toxins.

This is a wonderful thread.

Thanks.

Joan

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