nanoknife IRE for pancreatic cancer

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RE: nanoknife IRE for pancreatic cancer

by PhilipJax on Sun Nov 18, 2018 01:28 PM

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CAR-T For Liver Metastases
Good Effect When Delivered Under Pressure

Everyone:
          For Stage 4 pancreatic patients the presence of liver metastases makes them ineligible for surgical resection and possible cure.
          In a new development researchers recently presented data on immunotherapy for liver metastases: Anti-CEA CAR-T delivered using a new form of Hepatic Arterial Infusion (HAI) called Pressure-Enabled Drug Delivery (PEDD).  The event was the Society for Immunotherapy of Cancer (SITC) Annual Meeting, November 7-11, 2018.
          The exceedingly small Phase 1b trial treated 4 pancreatic patient and one colorectal cancer patient.  These are the findings:
1. After treatment 2 of 4 (50%) pancreatic patients experienced Complete Responses (CR), no viable liver metastases as determined by PET scan.  One of the two is still alive after 19.3 months; the other did not do so well.
2. The more successful CR patient had undergone only one prior treatment regimen (FOLFIRINOX) and received a second CAR-T infusion 13 months after the first dose.  The other CR had undergone 6 prior chemo regimens.  They suffered 7 and 6 liver metastases, respectively.
3. For pancreatic patients the Median Overall Survival (OS) was 8.4 months.
4. PEDD significantly increased CAR-T more than five-fold within liver metastases, when compared with low-pressure microcatheters.  PEDD direct-delivery overpowers the high pressure within solid tumors and avoids the severely limiting side effects of systemic therapy such as neurotoxicity.  
          Unfortunately this trial NCT02850536 is no longer recruiting.  However, the next trial phase could start within a year.  Contact the trail leaders.  See
https://clinicaltrials.gov/ct2/show/NCT02850536
          The press release can be found here:
http://jaxelection.altervista.org/pancreatic/SorrentoCAR-T_S
          And, the detailed SITC poster presentation can be found here:
http://jaxelection.altervista.org/pancreatic/AntiCEA_CAR-T_H
          For more information on CAR-T therapy for pancreatic cancer download this article:
http://jaxelection.altervista.org/pancreatic/CAR-TPotentialP
          For more Pancreatic Cancer treatment information and a Decision Guide visit my website at
https://pancreatic.altervista.org/
         PhilipJax

RE: nanoknife IRE for pancreatic cancer

by Baloo on Mon Nov 19, 2018 03:48 PM

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Philipjax, thank you. As always your invaluable posts give hope to those of us that really, really need it.

RE: nanoknife IRE for pancreatic cancer

by saint_123 on Fri Nov 23, 2018 05:33 PM

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Phase 1b and a sample size of 4. Nevertheless, something to keep an eye on I suppose.

Can't thank you enough for your contribution in bringing the latest in research to this forum.

RE: nanoknife IRE for pancreatic cancer

by caseyzson on Thu Dec 06, 2018 05:05 PM

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Hi PhillipJax,

I looked on your decision guide and also this site, but it is hard to search - I was wondering what your thoughts of local Y90 radiation for the treatment of liver metastsis.  This is meant to hopefully extend the time for other new trials to join: 

http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e15

Rest of the cancer is stable.

Thank you!

RE: nanoknife IRE for pancreatic cancer

by caseyzson on Thu Dec 06, 2018 05:14 PM

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Please disregard, this question was already answered earlier.  Seems Proton is one of the better options..apologies.

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