Molecular Assay Predictive of Survival in resected NSCLC

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RE: Test could aid early-stage lung cancer patients

by Gdpawel on Fri Jan 27, 2012 05:46 AM

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I was wondering when someone was going to develop a test like this since the failed Lung Metagene Predictor, developed at Duke University Medical Center, that was supposed to tell physicians which lung cancer patients would benefit from chemotherapy and which ones would not need to be unnecessarily exposed to toxic chemotherapy cocktails.

The test doesn't predict which patients will benefit from chemotherapy (i.e. which patients are chemosensitive to actual therapies), rather it's like the Oncotype Dx test, which identifies patients who are unlikely to have a recurrence if treated with surgery alone. If you aren't going to have a recurrence, you don't need chemotherapy.

Improving cancer patient diagnosis and treatment through a combination of gene-based and cellular-based testing will offer predictive insight into the nature of an individual's particular cancer and enable oncologists to prescribe treatment more in keeping with the heterogeneity of the disease. The biologies are very different and the "individual" response to given drugs is very different.

RE: Test could aid early-stage lung cancer patients

by thebyrdsfriend on Fri Jan 27, 2012 01:47 PM

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Thank-you for this new information.  I know we still need so much research, but this is great to hear.

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